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Titolo:
Hypoxia-induced release of peptide growth factors from neonatal porcine pulmonary artery smooth muscle cells
Autore:
Ambalavanan, N; Bulger, A; Philips, JB;
Indirizzi:
Univ Alabama, Dept Pediat, Div Neonatol, Birmingham, AL 35249 USA Univ Alabama Birmingham AL USA 35249 v Neonatol, Birmingham, AL 35249 USA
Titolo Testata:
BIOLOGY OF THE NEONATE
fascicolo: 5, volume: 76, anno: 1999,
pagine: 311 - 319
SICI:
0006-3126(199911)76:5<311:HROPGF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA STABILITY; BFGF GENE; IN-VITRO; HYPERTENSION; EXPRESSION; PROLIFERATION; WALL; ACTIVATION; ENDOTHELIN; VEGF;
Keywords:
vascular smooth muscle cell; pulmonary vasculature; hypoxia; cell culture; fibroblast growth factor; platelet-derived growth factor; vascular endothelial growth factor; endothelin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Philips, JB Univ Alabama, Dept Pediat, Div Neonatol, H525,619 S 19th St, Birmingham, AL 35249 USA Univ Alabama H525,619 S 19th St Birmingham AL USA 35249 49 USA
Citazione:
N. Ambalavanan et al., "Hypoxia-induced release of peptide growth factors from neonatal porcine pulmonary artery smooth muscle cells", BIOL NEONAT, 76(5), 1999, pp. 311-319

Abstract

Peptide growth factors are involved in hypoxia-mediated neonatal pulmonaryvascular remodeling. The role of hypoxia in the release of selected peptide growth factors from neonatal porcine pulmonary artery smooth muscle cells(PASMC) was examined. PASMC were exposed to different oxygen tensions and the cells were counted electronically and the conditioned media analyzed for basic fibroblast growth factor (bFGF), endothelin-1 (ET-I), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF). The effect of conditioned media on PASMC proliferation was also measured. Hypoxia (1% oxygen) and hypoxia-conditioned media increased PASMC numbers, andthis mitogenic effect was abolished by anti-bFGF, but not by anti-PDGF or anti-VEGF. Hpyoxia increased bFGF and VEGF release but not PDGF or ET-1. This suggests that PASMC-derived bFGF and VEGF may participate in hypoxic neonatal pulmonary vascular remodeling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:26:23