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Titolo:
Symptom provocation studies in psychiatric disorders: Scientific value, risks, and future
Autore:
DSouza, DC; Berman, RM; Krystal, JH; Charney, DS;
Indirizzi:
VA Connecticut Healthcare Syst, Psychiat Serv, Schizophrenia Biol Res Ctr,W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA Connecticut Mental Hlth Ctr, Abraham Ribicoff Res Ctr, New Haven, CT USA Connecticut Mental Hlth Ctr New Haven CT USA Res Ctr, New Haven, CT USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 46, anno: 1999,
pagine: 1060 - 1080
SICI:
0006-3223(19991015)46:8<1060:SPSIPD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT-INDUCED REMISSION; CEREBRAL BLOOD-FLOW; TRYPTOPHAN DEPLETION; DEPRESSED-PATIENTS; PREFRONTAL CORTEX; SCHIZOPHRENIC SYMPTOMS; HEALTHY-VOLUNTEERS; DOPAMINE RELEASE; RAPID DEPLETION; CROSSOVER TRIAL;
Keywords:
symptom-provocation; benefits; risks; safeguards; bioethics; psychiatry institutional review board;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
153
Recensione:
Indirizzi per estratti:
Indirizzo: D'Souza, DC VA Connecticut Healthcare Syst, Psychiat Serv, Schizophrenia Biol Res Ctr,116A,950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst 116A,950 Campbell Ave W Haven CT USA 06516
Citazione:
D.C. D'Souza et al., "Symptom provocation studies in psychiatric disorders: Scientific value, risks, and future", BIOL PSYCHI, 46(8), 1999, pp. 1060-1080

Abstract

Several lines of investigation have contributed to the increasing recognition of the biological basis of psychiatric disorders. Symptom provocation studies have made important contributions toward this. With the emergence ofnovel methodologies, the role of symptom provocation studies has come under increasing scrutiny and debate. The scientific contributions and risks ofsymptom provocation studies are discussed using the psychostimulant paradigm in schizophrenia research as the prototypical study. The application of studies in other areas of medicine that carry risks similar to those associated with symptom provocation studies, are also reviewed. The authors draw on the parallel of cardiac stress testing to highlight risks:benefits issues. Finally, the authors discuss the future of symptom provocation studies and emphasize that these studies will need to meet the highest scientific tandards, ethical standards and safeguards. (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:55:57