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Titolo:
Massive myocardial necrosis in thrombotic thrombocytopenic purpura - A case report and review of the literature
Autore:
Podolsky, SH; Zembowicz, A; Schoen, FJ; Benjamin, RJ; Sonna, LA;
Indirizzi:
Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Care Med, Boston, MA 02115 USA
Titolo Testata:
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
fascicolo: 10, volume: 123, anno: 1999,
pagine: 937 - 940
SICI:
0003-9985(199910)123:10<937:MMNITT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONNECTIVE-TISSUE DISEASE; SYSTEMIC LUPUS-ERYTHEMATOSUS; FACTOR-CLEAVING PROTEASE; ASSOCIATION; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Benjamin, RJ Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA 02115 5 USA
Citazione:
S.H. Podolsky et al., "Massive myocardial necrosis in thrombotic thrombocytopenic purpura - A case report and review of the literature", ARCH PATH L, 123(10), 1999, pp. 937-940

Abstract

Thrombotic thrombocytopenic purpura (TTP) is an uncommon syndrome resulting from diffuse occlusion of small arterioles and capillaries by hyaline microthrombi. It is characterized by fever, thrombocytopenic purpura, microangiopathic hemolytic anemia, and neurologic and renal dysfunction. While cardiac pathology in TTP is commonly seen at autopsy, clinical cardiac dysfunction is rare and typically results from conduction system involvement. While3% to 8% of patients with TTP report chest pain on admission, reports of fatal ventricular pump failure are extremely rare. We now report a case of TTP resulting in death from widespread myocardial necrosis. This patient presented with elevated cardiac enzymes and electrocardiographic disturbances that mimicked viral myocarditis, bs well as a profound thrombocytopenia. Such a case may represent the extreme of a distribution of cardiac involvement in TTP or the consequence of an unidentified autoimmune process capable of precipitating severe myocardial TTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:24:14