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Titolo:
Evolution of genotypic resistance to nucleoside analogues in patients receiving protease inhibitor-containing regimens
Autore:
Perez-Olmeda, M; Rubio, A; Puig, T; Gomez-Cano, M; Ruiz, L; Leal, M; Clotet, B; Soriano, V;
Indirizzi:
Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain Inst Salud Carlos III Madrid Spain III, Infect Dis Serv, Madrid, Spain Virgen del Rocio Univ Hosp, Viral Hepatitis & AIDS Study Grp, Seville, Spain Virgen del Rocio Univ Hosp Seville Spain AIDS Study Grp, Seville, Spain Hosp Germans Trias & Pujol, Fundacio IrsiCaixa, HIV Unit, Barcelona, SpainHosp Germans Trias & Pujol Barcelona Spain , HIV Unit, Barcelona, Spain
Titolo Testata:
ANTIVIRAL THERAPY
fascicolo: 3, volume: 4, anno: 1999,
pagine: 179 - 181
SICI:
1359-6535(1999)4:3<179:EOGRTN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE GENE; ZIDOVUDINE; MUTATIONS; CODON-215; THERAPY; ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Soriano, V Inst Salud Carlos III, Infect Dis Serv, Madrid, Spain Inst Salud Carlos III Madrid Spain t Dis Serv, Madrid, Spain
Citazione:
M. Perez-Olmeda et al., "Evolution of genotypic resistance to nucleoside analogues in patients receiving protease inhibitor-containing regimens", ANTIVIR TH, 4(3), 1999, pp. 179-181

Abstract

The prevalence of genotypic resistance to nucleoside analogues (NA) was examined using a line probe assay (LiPA, Innogenetics, Spain) and a point mutation assay to test for codon 151 polymorphism in plasma from 34 individuals who had been exposed to NA for longer than 1 year. The testing was repeated in the same population after 6 months of being on a new potent protease inhibitor (PI)-containing antiretroviral combination. Only nine (47%) of the 19 patients initially carrying the codon 41 mutation restored zidovudine wild-type (WT) virus population. Similarly, eight (33%) out of 24 carrying the codon 215 mutation restored the wild-type variant. Two subjects carrying codon 74 didanosine mutation reverted to wild-type genotype, as well as two (18%) out of 11 harbouring the codon 184 lamivudine-resistant variant. To conclude, the extent to which drug recycling might be of benefit in subjects showing a restoration of genotypic sensitivity to former drugs needs tobe explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:11:49