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Titolo:
Diabetic cardiac autonomic dysfunction: parasympathetic versus sympathetic
Autore:
Uehara, A; Kurata, C; Sugi, T; Mikami, T; Shouda, S;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Med 3, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 2, volume: 13, anno: 1999,
pagine: 95 - 100
SICI:
0914-7187(199904)13:2<95:DCADPV>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; MIBG MYOCARDIAL SCINTIGRAPHY; I-123 METAIODOBENZYLGUANIDINE; SPECTRAL-ANALYSIS; NEUROPATHY; IODINE-123-MIBG; CARDIOMYOPATHY; MELLITUS; DISEASE; IDDM;
Keywords:
diabetic mellitus; autonomic nervous system; metaiodobenzylguanidine; heart rate variability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Uehara, A Hamamatsu Univ, Sch Med, Dept Med 3, 3600 Handa Cho, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313192 n
Citazione:
A. Uehara et al., "Diabetic cardiac autonomic dysfunction: parasympathetic versus sympathetic", ANN NUCL M, 13(2), 1999, pp. 95-100

Abstract

Diabetic cardiac autonomic dysfunction often causes lethal arrhythmia and sudden cardiac death. I-123-Metaiodobenzylguanidine (MIBG) can evaluate cardiac sympathetic dysfunction, and analysis of heart rate variability (HRV) can reflect cardiac parasympathetic activity. We examined whether cardiac parasympathetic dysfunction assessed by HRV may correlate with sympathetic dysfunction assessed by MIBG in diabetic patients. Methods and Results: In 24-hour electrocardiography, we analyzed 4 HRV parameters: high-frequency power (HF), HF in the early morning (EMHF), rMSSD and pNN50. MIBG planar images and SPECT were obtained 15 minutes (early) and150 minutes (late) after injection and the heart washout rate was calculated. The defect score in 9 left ventricular regions was scored on a 4 point scale (0 = normal similar to 3 = severe defect). In 20 selected diabetic patients without congestive heart failure, coronary artery disease and renal failure, parasympathetic HRV parameters had a negative correlation with thesum of defect scores (DS) in the late images (R = -0.47 similar to -0.59, p < 0.05) and some parameters had a negative correlation with the washout rate (R = -0.50 similar to -0.55, p < 0.05). In a total of 64 diabetic patients also, these parameters had a negative correlation with late DS (R = -0.28 similar to -0.35, p < 0.05) and early DS (R = -0.27 similar to -0.32, p < 0.05). Conclusions: The progress of diabetic cardiac parasympathetic dysfunction may parallel the sympathetic one.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:52:36