Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of three PET dopamine D-2-like receptor ligands, [C-11]raclopride, [C-11]nemonapride and [C-11]N-methylspiperone, in rats
Autore:
Ishiwata, K; Hayakawa, N; Ogi, N; Oda, K; Toyama, H; Endo, K; Tanaka, A; Senda, M;
Indirizzi:
Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, Tokyo 1730022, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730022 okyo 1730022, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 3, volume: 13, anno: 1999,
pagine: 161 - 167
SICI:
0914-7187(199906)13:3<161:COTPDD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; H-3 N-METHYLSPIPERONE; HIGH-RESOLUTION PET; D4 RECEPTORS; INVIVO BINDING; D-2 RECEPTORS; HIGH-AFFINITY; HUMAN-BRAIN; IN-VIVO; SCHIZOPHRENIA;
Keywords:
raclopride; nemonapride; N-methylspiperone; dopamine D-2-like receptor; rat; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiwata, K Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, 1-1 Naka,Tokyo 1730022, Japan Tokyo Metropolitan Inst Gerontol 1-1 Naka Tokyo Japan 1730022
Citazione:
K. Ishiwata et al., "Comparison of three PET dopamine D-2-like receptor ligands, [C-11]raclopride, [C-11]nemonapride and [C-11]N-methylspiperone, in rats", ANN NUCL M, 13(3), 1999, pp. 161-167

Abstract

We studied the tracer kinetics of three dopamine D-2-like receptor ligands, [C-11]raclopride ([C-11]RAC), [C-11]nemonapride ([C-11]NEM) and [C-11]N-methylspiperone ([C-11]MSP), in anesthetized rats by tissue dissection, ex vivo ARG and PET in order to clarify their characteristics for PET imaging. The in vivo affinity of the three ligands for the striatum ([C-11]MSP > [C-11]NEM > [C-11]RAC) obeyed the in vitro affinity for dopamine D-2 receptors. The affinity of [C-11]RAC and [C-11]MSP for the cerebellum was very low, but the affinity of [C-11]NEM for the cerebellum was compatible to that forthe cortex and was not to be ignored. Also the affinity of [C-11]MSP for the cortex was relatively high. [C-11]RAC showed the highest selectivity. The striatal PET image with [C-11]RAC was clearer than that with [C-11]NEM or[C-11]MSP, but the activity decreased much faster than that measured by tissue dissection because of the partial volume effect. The striatal activitywith [C-11]NEM remained high and that with [C-11]MSP gradually increased. [C-11]RAC and [C-11]MSP, but not [C-11]NEM, showed a high accumulation in the periorbital region.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:06:30