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Titolo:
Mechanism for abnormal thallium-201 myocardial scintigraphy in patients with left bundle branch block in the absence of angiographic coronary artery disease
Autore:
Hasegawa, S; Sakata, Y; Ishikura, F; Hirayama, A; Kusuoka, H; Nishimura, T; Kodama, K;
Indirizzi:
Osaka Univ, Grad Sch Med D9, Biomed Res Ctr, Div Tracer Kinet, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 r Kinet, Suita, Osaka 5650871, Japan Osaka Univ, Grad Sch Med, Dept Med 1, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Med 1, Suita, Osaka 5650871, Japan Osaka Police Hosp, Div Cardiovasc, Osaka, Japan Osaka Police Hosp Osaka Japan Police Hosp, Div Cardiovasc, Osaka, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 4, volume: 13, anno: 1999,
pagine: 253 - 259
SICI:
0914-7187(199908)13:4<253:MFATMS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; TL-201 SCINTIGRAPHY; EXERCISE TL-201; GLUCOSE-METABOLISM; SEPTAL PERFUSION; ADENOSINE TL-201; DIPYRIDAMOLE; ACCURACY;
Keywords:
left bundle branch block; thallium; MIBI; gated SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hasegawa, S Osaka Univ, Grad Sch Med D9, Biomed Res Ctr, Div Tracer Kinet,2-2 Yamada Oka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamada Oka Suita Osaka Japan 5650871 871, Japan
Citazione:
S. Hasegawa et al., "Mechanism for abnormal thallium-201 myocardial scintigraphy in patients with left bundle branch block in the absence of angiographic coronary artery disease", ANN NUCL M, 13(4), 1999, pp. 253-259

Abstract

Patients with left bundle branch block (LBBB) often show abnormal images on exercise thallium (T1)-201 scintigraphy without evidence of significant coronary stenosis. We investigated the mechanism for this phenomenon. Six patients with LBBB and without significant coronary stenosis underwent T1-201SPECT, ECG-gated SPECT imaging with Tc-99m-methoxyisobutyl-isonitrile (MIBI), and atrial pacing stress test. The % count amplitude in Tc-99m-MIBI images was calculated as I(maximal counts) - {(minimal counts)}/(minimal counts)x 100. Though all patients had a low count in the septal and inferior wall in T1-201 SPECT images, there was no ischemic production of lactate during nn atrial pacing stress test Nevertheless gated SPECT images showed attenuated septal activity during systole. In patients with LBBB, the ratios of % count amplitude at the septum to that at the lateral wall at rest (0.47 +/- 0.05, mean +/- SE) were significantly less than the controls (n = 5, 0.83 +/- 0.12, p = 0.014). In conclusion, these results suggest that abnormal T1-201 SPECT images of the septum in patients with LBBB are partially caused by impaired septal wall thickening during systole. Such an abnormal wall motion may reduce blood flow demands to the septum, resulting in reduction of coronary blood flow with little ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:33:50