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Titolo:
SCHEDULE-INDUCED POLYDIPSIC CHOICE BETWEEN COCAINE AND LIDOCAINE SOLUTIONS - CRITICAL IMPORTANCE OF ASSOCIATIVE HISTORY
Autore:
LAU CE; NEAL SA; FALK JL;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903 RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903
Titolo Testata:
Behavioural pharmacology
fascicolo: 8, volume: 7, anno: 1996,
pagine: 731 - 741
SICI:
0955-8810(1996)7:8<731:SPCBCA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE MOTOR FUNCTIONS; SELF-ADMINISTERED COCAINE; ORALLY DELIVERED COCAINE; STIMULUS-CONTROL; RHESUS-MONKEYS; PHARMACOKINETICS; REINFORCER; HUMANS;
Keywords:
ASSOCIATIVE HISTORY; COCAINE; DRUG CHOICE; DRUG PREFERENCE; LIDOCAINE; ORAL DRUG; ORAL SELF-ADMINISTRATION; RAT; SCHEDULE-INDUCED BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C.E. Lau et al., "SCHEDULE-INDUCED POLYDIPSIC CHOICE BETWEEN COCAINE AND LIDOCAINE SOLUTIONS - CRITICAL IMPORTANCE OF ASSOCIATIVE HISTORY", Behavioural pharmacology, 7(8), 1996, pp. 731-741

Abstract

Two groups of rats given daily, 3-h, intermittent food-pellet sessions, which induced polydipsia, drank either cocaine (COG) or lidocaine (LIDO) solutions, Then water was made available concurrently, but neither group preferred drug solution, When drug was presented in a glucose-saccharin vehicle, which was subsequently faded out, both the COC andLIDO groups acquired a strong preference for drug solution rather than water, Half of each group was continued, and half was directly fadedto a preference for the other drug solution rather than water, Then COC and LIDO solutions were available concurrently and animals overwhelmingly preferred the drug solution that historically had been associated with the glucose-saccharin vehicle, Finally, the COG-preferring andLIDO-preferring groups had the concentrations of their preferred drugincreased step-wise several times and preferences were maintained, Thus, acquired drug preferences remained stable as preferred drug concentration was increased, making it more bitter than the nonpreferred drug, The abuse potential of COC affords it little advantage over LIDO inthe institution and maintenance of oral drug preference, suggesting that the post-ingestive pharmacological action of a drug is less important for acquiring drug-taking than is a history of associating the drug with another reinforcing event.

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Documento generato il 03/04/20 alle ore 08:00:00