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Titolo:
Inhibition of DNA synthesis in isolated human endometrial cells by a levonorgestrel-releasing intrauterine device
Autore:
Luo, HZ; Zhu, PD; Xu, RH; Cheng, J; Zhao, XD; Wang, JD;
Indirizzi:
Natl Res Inst Family Planning, Beijing 100081, Peoples R China Natl Res Inst Family Planning Beijing Peoples R China 100081 les R China
Titolo Testata:
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY
fascicolo: 5, volume: 21, anno: 1999,
pagine: 409 - 412
SICI:
0884-6812(199910)21:5<409:IODSII>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM USE; OVARIAN-FUNCTION; IUD; CONTRACEPTION;
Keywords:
DNA synthesis inhibitors; intrauterine devices; medicated; levonorgestrel; endometrium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, JD Natl Res Inst Family Planning, 12 Da Hiu Si, Beijing 100081, Peoples R China Natl Res Inst Family Planning 12 Da Hiu Si Beijing Peoples R China 100081
Citazione:
H.Z. Luo et al., "Inhibition of DNA synthesis in isolated human endometrial cells by a levonorgestrel-releasing intrauterine device", ANAL QUAN C, 21(5), 1999, pp. 409-412

Abstract

OBJECTIVE: To estimate the effect of an intrauterine device (IUD) releasing 20 mu g levonorgestrel (LNG) per 24 hours on DNA synthesis in human endometrial cells before and after 12 months of use. STUDY DESIGN: Endometrial specimens were collected from the anterior or posterior wall of the miduterus from 6 females on cycle day 10-12 before insertion of the IUD and after 12 months of use. RESULTS: Previous results from our group did not reveal any influence on endometrial DNA cell content when a levonorgestrel IUD releasing 2 mu g/24 hwas used for 12 months in a group of fertile females. In this study, the IUD release rate, 20 mu g LNG/24 h, was statistically significantly different from the results in the previous studies. The effect of the levonorgestrel IUD on endometrial proliferation was dose dependent, and a significant correlation could be found between continuous exposure to LNG ann inhibition of DNA synthesis in endometrial cells. CONCLUSION: Inhibition of proliferative activity in endometrial cells seems to be reflected by a decrease in DNA synthesis per cell nucleus and contributes to the clinical performance of the LNG-releasing IUD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:12:51