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Titolo:
Blood volumes and renal function in overt and subclinical primary hypothyroidism
Autore:
Villabona, C; Sahun, M; Roca, M; Mora, J; Gomez, N; Gomez, JM; Puchal, R; Soler, J;
Indirizzi:
Univ Barcelona, Dept Endocrinol, Barcelona, Spain Univ Barcelona Barcelona Spain elona, Dept Endocrinol, Barcelona, Spain Univ Barcelona, Dept Nucl Med, Barcelona, Spain Univ Barcelona BarcelonaSpain rcelona, Dept Nucl Med, Barcelona, Spain
Titolo Testata:
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
fascicolo: 4, volume: 318, anno: 1999,
pagine: 277 - 280
SICI:
0002-9629(199910)318:4<277:BVARFI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EDEMA; DYNAMICS; PROTEIN;
Keywords:
blood volumes; renal function; hypothyroidism; subclinical hypothyroidism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Villabona, C 55 Sant Quirze del Valles, Barcelona, Spain 55 Sant Quirze del Valles Barcelona Spain Barcelona, Spain
Citazione:
C. Villabona et al., "Blood volumes and renal function in overt and subclinical primary hypothyroidism", AM J MED SC, 318(4), 1999, pp. 277-280

Abstract

Introduction: Thyroid dysfunction is associated with marked alterations incardiovascular and renal functions. In hypothyroidism, myocardial contractility, cardiac output, and oxygen consumption are decreased, whereas peripheral resistance is increased. Methods: We assessed blood volumes and effective renal plasma blood flow (ERPF) and glomerular filtration rate (GFR) in 17 patients with overt primary hypothyroidism and in 15 of these patients when in euthyroid state after substitutive therapy. We performed the same measurements in eight patients with subclinical hypothyroidism. Results: In the hypothyroid state, the plasma volume measured by dilution of I-125-albumin (APV) was higher than the calculated plasma volume (CPV) from packed redcell mass, suggesting an extravascular escape of albumin. After substitutive therapy, the CPV showed a statistical increase (P < 0.05), whereas APV remained unchanged. Both ERPF and GFR increased after thyroxine therapy (p <0.05). In the subclinical group, blood volumes and renal function were similar to those found in the other group of patients when in the euthyroid state. Conclusions: We conclude that in primary hypothyroidism, ERPF and GFR are low, but that these values improve with substitutive therapy. CPV is a better index of the current plasma volume than APV. The difference between these two parameters suggests that the escape of albumin into the extravascular space in primary hypothyroidism is terminated by treatment. There are no clear abnormalities either in blood volumes or in renal function in subclinical hypothyroidism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:41:20