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Titolo:
Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection
Autore:
Quintanilla-Martinez, L; Fend, F; Moguel, LR; Spilove, L; Beaty, MW; Kingma, DW; Raffeld, M; Jaffe, ES;
Indirizzi:
NCI, NIH, Hematopathol Sect, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 NIH, Hematopathol Sect, Bethesda, MD 20892 USA Inst Mexicano Seguro Social, Dept Pathol, Merida, Yucatan, Mexico Inst Mexicano Seguro Social Merida Yucatan Mexico erida, Yucatan, Mexico Danbury Hosp, Dept Pathol, Danbury, CT USA Danbury Hosp Danbury CT USADanbury Hosp, Dept Pathol, Danbury, CT USA
Titolo Testata:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 10, volume: 23, anno: 1999,
pagine: 1233 - 1240
SICI:
0147-5185(199910)23:10<1233:PTLWRC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKINS-LYMPHOMAS; LASER CAPTURE MICRODISSECTION; GENE REARRANGEMENTS; DISEASE; EXPRESSION; TRANSFORMATION; ORIGIN; CLONE;
Keywords:
Epstein-Barr virus; Hodgkin's disease; T-cell lymphomas; angioimmunoblastic T-cell lymphoma; microdissection; polymerase chain reaction; immunophenotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Jaffe, ES NCI, NIH, Hematopathol Sect, Bldg 10,Room 2N202,10 Ctr Dr,MSC 1500, Bethesda, MD 20892 USA NCI Bldg 10,Room 2N202,10 Ctr Dr,MSC 1500 Bethesda MD USA 20892
Citazione:
L. Quintanilla-Martinez et al., "Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection", AM J SURG P, 23(10), 1999, pp. 1233-1240

Abstract

We report three cases of nodal peripheral T-cell lymphoma (PTCL) with Reed-Sternberg-like (RS-Like) cells of B-cell pheno- and/or genotype. Histologic analysis in all cases revealed diffuse nodal effacement by atypical lymphoid cells of variable size. Two of the three cases had features of angioimmunoblastic T-cell lymphoma (AILT). Large mononuclear and binucleated cells with prominent eosinophilic nucleoli and abundant cytoplasm resembling classic RS cells and mononuclear variants were scattered throughout all biopsies. The lymphoma cells in the three cases were of T-cell lineage (CD3+, CD43, and CD45RO+). The RS-like cells from all cases were CD30 and CD15 positive. In contrast to the neoplastic T cells, the RS-like cells lacked all T-cell markers and in two cases were positive for CD20. Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) and EBER 1 (2/2) were detected in the RS-like cells in all cases. The neoplastic T cells were negative for EBV. Polymerase chain reaction (PCR) analysis demonstrated clonal rearrangements of the T-cell receptor gamma chain gene in the three cases. PCR analysis of microdissected RS-like cells for immunoglobulin heavy chain gene rearrangements in cases 1 and 3 showed an oligoclonal pattern. The presence of RS-like cells in PTCL represents a diagnostic pitfall, because in one case this observation led to a misdiagnosis of Hodgkin's disease (HD), The oligoclonalexpansion of EBV-infected cells may be related to underlying immunodeficiency associated with T-cell lymphomas and AILT in particular. This phenomenon may provide the basis for some cases of Hodgkin's disease after T-cell lymphomas and suggests that they are clonally unrelated neoplasms. The expression of LMP1 appears to be crucial for the immunophenotype and probably forthe morphology of the RS and RS-like cells appearing in diverse lymphoid malignancies, including HD, chronic lymphocytic leukemia, and PTCL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:27:48