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Titolo:
A combination of abnormal immunoarchitecture and reproducible clonal bandsidentifies the biologic nature of cutaneous B-cell infiltrates
Autore:
Saxena, A; Angel, S; Geldenhuys, L; Hull, PR;
Indirizzi:
Univ Saskatchewan, Royal Univ Hosp, Dept Pathol, Saskatoon, SK S7N 0W8, Canada Univ Saskatchewan Saskatoon SK Canada S7N 0W8 skatoon, SK S7N 0W8, Canada Univ Saskatchewan, Royal Univ Hosp, Div Dermatol, Dept Internal Med, Saskatoon, SK S7N 0W8, Canada Univ Saskatchewan Saskatoon SK Canada S7N 0W8 skatoon, SK S7N 0W8, Canada
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 4, volume: 112, anno: 1999,
pagine: 495 - 512
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; IMMUNOGLOBULIN GENE REARRANGEMENTS; FOLLICULAR LYMPHOID HYPERPLASIA; MALIGNANT-LYMPHOMA; T-CELL; LYMPHOPROLIFERATIVE DISEASES; BENIGN; TISSUE; SKIN; ORIGIN;
Keywords:
immunoarchitecture; clonality; cutaneous B-cell infiltrates; cutaneous lymphoid hyperplasia; cutaneous B-cell lymphoma; immunohistochemistry; polymerase chain reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Saxena, A Univ Saskatchewan, Royal Univ Hosp, Dept Pathol, 103 Hosp Dr, Saskatoon, SK S7N 0W8, Canada Univ Saskatchewan 103 Hosp Dr Saskatoon SK Canada S7N 0W8 Canada
Citazione:
A. Saxena et al., "A combination of abnormal immunoarchitecture and reproducible clonal bandsidentifies the biologic nature of cutaneous B-cell infiltrates", AM J CLIN P, 112(4), 1999, pp. 495-512

Abstract

In the multiparametric evaluation of cutaneous B-cell infiltrates (CBIs), immunoarchitectural features have been underused, and B-cell clonality alone has limited clinical usefulness. Our aim was to assess the usefulness of immunoarchitectural abnormalities (IAs) and clonality in the diagnosis of CBIs. On 39 CBIs, immunohistochemistry was performed using anti-CD45, antt-CD45RO, anti-CD3, anti-CD20, anti-CD21, and anti-CD35, and polymerase chain reaction was used to detect immunoglobulin heavy chain rearrangement. Therewere 33 cutaneous lymphoid hyperplasias (CLHs) and 6 cutaneous B-cell lymphomas. IAs were present in 9 lesions and clonal bands in 14 lesions. In 6 cutaneous B-cell lymphomas, IAs were associated with pure and reproducible clonal bands. IAs in 3 CLH lesions with a superficial infiltrate were not associated with clonal bands. Clonal bands in 8 CLH lesions without IAs were not reproducible from deeper sections; furthermore, in 5 of 8 cases, these were present against a background smear A combination of IAs and clonality is a useful adjunct in the diagnosis of CBIs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:25:36