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Titolo:
Pharmacogenomics: Translating functional genomics into rational therapeutics
Autore:
Evans, WE; Relling, MV;
Indirizzi:
St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 ci, Memphis, TN 38105 USA Univ Tennessee, Coll Pharm, Memphis, TN 38105 USA Univ Tennessee Memphis TN USA 38105 ee, Coll Pharm, Memphis, TN 38105 USA Univ Tennessee, Coll Med, Memphis, TN 38105 USA Univ Tennessee Memphis TNUSA 38105 ssee, Coll Med, Memphis, TN 38105 USA
Titolo Testata:
SCIENCE
fascicolo: 5439, volume: 286, anno: 1999,
pagine: 487 - 491
SICI:
0036-8075(19991015)286:5439<487:PTFGIR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME GENE; ACUTE LYMPHOBLASTIC-LEUKEMIA; POLYMORPHIC DRUG-METABOLISM; RECEPTOR GENE; THIOPURINE METHYLTRANSFERASE; TARDIVE-DYSKINESIA; P-GLYCOPROTEIN; DIHYDROPYRIMIDINE DEHYDROGENASE; ESSENTIAL-HYPERTENSION; POOR METABOLIZERS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Evans, WE St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Res Hosp 332 N Lauderdale St Memphis TN USA 38105
Citazione:
W.E. Evans e M.V. Relling, "Pharmacogenomics: Translating functional genomics into rational therapeutics", SCIENCE, 286(5439), 1999, pp. 487-491

Abstract

Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:02:39