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Titolo:
HIP1, A HUMAN HOMOLOG OF SACCHAROMYCES-CEREVISIAE SLA2P, INTERACTS WITH MEMBRANE-ASSOCIATED HUNTINGTIN IN THE BRAIN
Autore:
KALCHMAN MA; KOIDE HB; MCCUTCHEON K; GRAHAM RK; NICHOL K; NISHIYAMA K; KAZEMIESFARJANI P; LYNN FC; WELLINGTON C; METZLER M; GOLDBERG YP; KANAZAWA I; GIETZ RD; HAYDEN MR;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT MED GENET,NCE BLDG,ROOM 416,2125 E MALL VANCOUVER BC V6T 1Z4 CANADA UNIV BRITISH COLUMBIA,DEPT MED GENET VANCOUVER BC V6T 1Z4 CANADA UNIV TOKYO,FAC MED,DEPT CLIN NEUROL & NEUROSCI TOKYO 113 JAPAN UNIV MANITOBA,FAC MED,DEPT HUMAN GENET WINNIPEG MB R3E 0W3 CANADA
Titolo Testata:
Nature genetics
fascicolo: 1, volume: 16, anno: 1997,
pagine: 44 - 53
SICI:
1061-4036(1997)16:1<44:HAHHOS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; REPEAT LENGTH; LEUCINE-ZIPPER; DISEASE; PROTEIN; GENE; EXPRESSION; CYTOSKELETON; EXPANSION; IDENTIFY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Kalchman et al., "HIP1, A HUMAN HOMOLOG OF SACCHAROMYCES-CEREVISIAE SLA2P, INTERACTS WITH MEMBRANE-ASSOCIATED HUNTINGTIN IN THE BRAIN", Nature genetics, 16(1), 1997, pp. 44-53

Abstract

Huntington disease (HD) is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. Here we describe a novel huntingtin interacting protein, HIP1, which co-localizes with huntingtin and shares sequence homology and biochemical characteristics with Sla2p, a protein essential for function of the cytoskeleton in Saccharomyces cerevisiae. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in huntingtin. This provides the first molecular link between huntingtin and the neuronal cytoskeleton and suggests that, in HD, loss of normal huntingtin-HIP1 interaction may contribute to a defect in membrane-cytoskeletal integrity in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:31:32