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Titolo:
Growth hormone stimulation test results as predictors of recombinant humangrowth hormone treatment outcomes: Preliminary analysis of the National Cooperative Growth Study database
Autore:
Bright, GM; Julius, JR; Lima, J; Blethen, SL;
Indirizzi:
Nemours Childrens Clin, Ctr Pharmacokinet & Pharmacodynam Res, Jacksonville, FL 32207 USA Nemours Childrens Clin Jacksonville FL USA 32207 cksonville, FL 32207 USA Nemours Childrens Clin, Dept Pediat Endocrinol, Jacksonville, FL 32207 USANemours Childrens Clin Jacksonville FL USA 32207 cksonville, FL 32207 USA Genentech Inc, Med Affairs, S San Francisco, CA 94080 USA Genentech Inc SSan Francisco CA USA 94080 S San Francisco, CA 94080 USA
Titolo Testata:
PEDIATRICS
fascicolo: 4, volume: 104, anno: 1999, supplemento:, S
pagine: 1028 - 1031
SICI:
0031-4005(199910)104:4<1028:GHSTRA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENCY; THERAPY;
Keywords:
growth hormone stimulation tests; recombinant human growth hormone; pharmacokinetic parameters; maximal stimulated growth hormone concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Lima, J Nemours Childrens Clin, Ctr Pharmacokinet & Pharmacodynam Res, 807Nira St, Jacksonville, FL 32207 USA Nemours Childrens Clin 807 Nira St Jacksonville FL USA 32207 7 USA
Citazione:
G.M. Bright et al., "Growth hormone stimulation test results as predictors of recombinant humangrowth hormone treatment outcomes: Preliminary analysis of the National Cooperative Growth Study database", PEDIATRICS, 104(4), 1999, pp. 1028-1031

Abstract

Growth hormone (GH) stimulation tests are considered a prerequisite to clinical trials of recombinant human GH (rhGH) therapy, but the test results may not be predictive of the treatment outcomes with rhGH. We examined the GH stimulation test results as a predictor of the treatment outcome in a cohort of prepubertal subjects in the National Cooperative Growth Study. A standard is proposed in which a diagnosis of GH deficiency is considered appropriate when a patient has significant first-year catch-up growth and that apositive stimulation test result predicts this outcome. With this construct, a traditional interpretation of GH stimulation test results correctly identifies 64% of the rhGH treatment outcomes. The analysis shows an upper limit of diagnostic sensitivity of 82% and a lower limit of specificity of 25% in our study population. The results of our recent studies suggest that the sensitivity and specificity of the current GH stimulation tests are attributable in part to broad intersubject variation in GH clearance, rates of GH elimination, and GH volume of distribution. The combined studies suggestthat the use of subject-specific pharmacokinetic parameters will improve the diagnostic interpretation of GH stimulation test results and improve rhGH treatment outcomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:50:13