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Titolo:
BIMOLECULAR EXON LIGATION BY THE HUMAN SPLICEOSOME
Autore:
ANDERSON K; MOORE MJ;
Indirizzi:
BRANDEIS UNIV,DEPT BIOCHEM,WM KECK INST CELLULAR VISUALIZAT WALTHAM MA 02254 BRANDEIS UNIV,DEPT BIOCHEM,WM KECK INST CELLULAR VISUALIZAT WALTHAM MA 02254
Titolo Testata:
Science
fascicolo: 5319, volume: 276, anno: 1997,
pagine: 1712 - 1716
SICI:
0036-8075(1997)276:5319<1712:BELBTH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRE-MESSENGER-RNA; MAMMALIAN INTRONS; SPLICING INVITRO; SITE SELECTION; SEQUENCE; PRECURSORS; TRANS; ENHANCER; PROTEINS; LENGTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
K. Anderson e M.J. Moore, "BIMOLECULAR EXON LIGATION BY THE HUMAN SPLICEOSOME", Science, 276(5319), 1997, pp. 1712-1716

Abstract

Intron excision is an essential step in eukaryotic gene expression, but the molecular mechanisms by which the spliceosome accurately identifies splice sites in nuclear precursors to messenger RNAs (pre-mRNAs) are not well understood. A bimolecular assay for the second step of splicing has now revealed that exon ligation by the human spliceosome does not require covalent attachment of a 3' splice site to the branch site. Furthermore, accurate definition of the 3' splice site in this system is independent of either a covalently attached polypyrimidine tract or specific 3' exon sequences. Rather, in this system 3' splice site selection apparently occurs with a 5' --> 3' directionality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:55:23