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Titolo:
Anatomic asymmetries of the posterior superior temporal lobes: A postmortem study
Autore:
Anderson, B; Southern, BD; Powers, RE;
Indirizzi:
Vet Adm Med Ctr, Neurol Serv, Birmingham, AL 35233 USA Vet Adm Med Ctr Birmingham AL USA 35233 ol Serv, Birmingham, AL 35233 USA Univ Alabama, Dept Neurol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Neurol, Birmingham, AL 35294 USA Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ept Pathol, Birmingham, AL 35294 USA Univ Alabama, Dept Psychiat, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 t Psychiat, Birmingham, AL 35294 USA
Titolo Testata:
NEUROPSYCHIATRY NEUROPSYCHOLOGY AND BEHAVIORAL NEUROLOGY
fascicolo: 4, volume: 12, anno: 1999,
pagine: 247 - 254
SICI:
0894-878X(199910)12:4<247:AAOTPS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLANUM TEMPORALE; NEUROFILAMENT PROTEIN; PROJECTION NEURONS; MACAQUE MONKEY; SPEECH REGION; LANGUAGE AREA; BRAIN; SPECIALIZATION; PERCEPTION; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Anderson, B Vet Adm Med Ctr, Neurol Serv, 127,700 S 19th St, Birmingham, AL 35233 USA Vet Adm Med Ctr 127,700 S 19th St Birmingham AL USA 35233 USA
Citazione:
B. Anderson et al., "Anatomic asymmetries of the posterior superior temporal lobes: A postmortem study", NEUROPS NEU, 12(4), 1999, pp. 247-254

Abstract

Objective: To examine for structural asymmetries in the posterior superiortemporal lobe at the microscopic level in an effort to explain the gross anatomical and functional asymmetries of this brain region. Background: The posterior superior temporal lobe is typically larger on the left and damageto this area frequently results in an aphasia. This has led to the hypothesis that the structural asymmetry determines the functional asymmetry, but no definite confirmation of this hypothesis exists. Methods: Sixteen men were studied at postmortem. Posterior superior temporal lobe dimensions, graymatter Volume, white matter volume, SMI-32 immunopositive neuronal density, and glia cell Volume were measured for both the left and right hemispheres. In a subset of eight subjects, myelin sheath and axon diameters were measured with electron microscopy. Results: Posterior superior temporal lobe white matter volume was greater on the left (p = 0.003, t test for dependentsamples). This asymmetry did not appear to be the result of an isolated proliferation of glia (p = 0.46, t test for dependent samples), nor the density of cortical to cortical projections neurons in the overlying cortex (p =0.71, t test for dependent samples). In a subset of eight subjects studiedwith electron microscopy, axons of the left posterior superior temporal lobe were more thickly myelinated (57 nm [SD = 27] left, 46 nm [SD = 24], p <0.001, ANOVA). Conclusions: As axons with thicker myelin sheaths conduct faster and require a greater volume, these results suggest asymmetry of myelination as an explanation for both a left hemisphere dominance for rapid sensory signal processing, leading to a functional asymmetry for language, and a larger left planum temporale.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:59:35