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Titolo:
Expression of p21 and MDM-2 proteins on tumor cells in responding and non-responding patients with Hodgkin's disease
Autore:
Smolewski, P; Niewiadomska, H; Krykowskii, E; Robak, T;
Indirizzi:
Med Univ Lodz, Dept Hematol, PL-93513 Lodz, Poland Med Univ Lodz Lodz Poland PL-93513 , Dept Hematol, PL-93513 Lodz, Poland Med Univ Lodz, Dept Oncol, PL-93513 Lodz, Poland Med Univ Lodz Lodz Poland PL-93513 dz, Dept Oncol, PL-93513 Lodz, Poland
Titolo Testata:
NEOPLASMA
fascicolo: 4, volume: 46, anno: 1999,
pagine: 212 - 218
SICI:
0028-2685(1999)46:4<212:EOPAMP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; WILD-TYPE P53; NUCLEAR ANTIGEN; LYMPHOMAS; GENE; BCL-2; OVEREXPRESSION; MUTATIONS; ABSENCE;
Keywords:
apoptosis; oncoproteins expression; Hodgkin's disease; prognostic factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Smolewski, P Med Univ Lodz, Dept Hematol, PL-93513 Lodz, Poland Med Univ Lodz Lodz Poland PL-93513 l, PL-93513 Lodz, Poland
Citazione:
P. Smolewski et al., "Expression of p21 and MDM-2 proteins on tumor cells in responding and non-responding patients with Hodgkin's disease", NEOPLASMA, 46(4), 1999, pp. 212-218

Abstract

Since the prevention of apoptosis can produce resistance to chemotherapy, abnormal expression of oncoproteins engaged in the regulation of this phenomenon in tumor cells may give some prognostic information in patients with neoplasma. To assess this problem in Hodgkin's disease (HD), the cellular expression of two p53 downstreams proteins p21 and MDM-2 was evaluated in the lymph nodes specimens obtained from 68 patients at the time of diagnosis,and compared with some clinical and pathological data. Positive immunoreaction for p21 and MDM-2 on Reed-Sternberg/Hodgkin's (R-S/H) cells was found in a majority of cases (58.8 and 63.2%, respectively). High expression of p21 protein correlated with poor response to the first-line treatment and disease free survival in both univariate and multivariate regression analysis, whereas expression of MDM-2 did not give prognostic information in patients with KD. Expression of p21 and MDM-2 was also compared with p53 protein immunoreactivity of R-S/H cells. The p21+/p53+ immunophenotype occurred to give particularly negative prognostic information in patients with HD. Diversity of p21/MDM-2/p53 patterns of R-S/H cells observed in particular patients may reflect heterogeneity of apoptosis regulatory mechanisms, as well as differences in p53 gene status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:24:14