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Titolo:
Positron emission tomographic studies in restless legs syndrome
Autore:
Trenkwalder, C; Walters, AS; Hening, WA; Chokroverty, S; Antonini, A; Dhawan, V; Eidelberg, D;
Indirizzi:
Max Planck Inst Psychiat, Dept Neurol, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08903 USA Univ Med & Dent New Jersey New Brunswick NJ USA 08903 swick, NJ 08903 USA VA Med Ctr, Neurol Serv, Lyons, NJ USA VA Med Ctr Lyons NJ USAVA Med Ctr, Neurol Serv, Lyons, NJ USA St Vincents Hosp & Med Ctr, Dept Neurol, New York, NY 10011 USA St Vincents Hosp & Med Ctr New York NY USA 10011 , New York, NY 10011 USA N Shore Univ Hosp, Movement Disorders Ctr, Manhasset, NY USA N Shore Univ Hosp Manhasset NY USA ment Disorders Ctr, Manhasset, NY USA NYU, Sch Med, Manhasset, NY USA NYU Manhasset NY USANYU, Sch Med, Manhasset, NY USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 1, volume: 14, anno: 1999,
pagine: 141 - 145
SICI:
0885-3185(199901)14:1<141:PETSIR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN TRANSFER CONSTANTS; F-18 DOPA UPTAKE; TIME UPTAKE DATA; PARKINSONS-DISEASE; PERIODIC MOVEMENTS; SPINAL-CORD; GRAPHICAL EVALUATION; NOCTURNAL MYOCLONUS; DOUBLE-BLIND; SLEEP;
Keywords:
restless legs syndrome (RLS); periodic limb movements (PLM); sleep disorders; positron emission tomography (PET); fluorodopa; fluorodeoxyglucose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Trenkwalder, C Max Planck Inst Psychiat, Dept Neurol, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
C. Trenkwalder et al., "Positron emission tomographic studies in restless legs syndrome", MOVEMENT D, 14(1), 1999, pp. 141-145

Abstract

We studied six restless legs syndrome (RLS) patients with [F18]fluorodeoxyglucose (FDG) positron emission tomography (PET). We also studied four of these same patients with [F18]fluorodopa (FDOPA) PET. The patients' FDG and FDOPA PET scans were compared with those from age-matched healthy control subjects. No significant differences between the two groups were found for any regional blood flow values derived from the FDG scans or for any bindingconstants derived from the FDOPA scans. These results suggest that any abnormal resting brain metabolic activity or putative presynaptic dopaminergicdefect in RLS is likely either to be so subtle that it is below the threshold for ready detection by PET or that it is located in an area of neural tissue inaccessible to the current scanner. No substantial defect is likely to involve the dopaminergic nigrostriatal axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:24:57