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Titolo:
CYP2D6 polymorphism and Parkinson's disease susceptibility
Autore:
Sabbagh, N; Brice, A; Marez, D; Durr, A; Legrand, M; Lo Guidice, JM; Destee, A; Agid, Y; Broly, F;
Indirizzi:
Ctr Hosp Reg & Univ Lille, Hop Calmette, Lab Biochim & Biol Mol, F-59037 Lille, France Ctr Hosp Reg & Univ Lille Lille France F-59037 ol, F-59037 Lille, France Ctr Hosp Reg & Univ Lille, Serv Neurol A, F-59037 Lille, France Ctr Hosp Reg & Univ Lille Lille France F-59037 A, F-59037 Lille, France Hop La Pitie Salpetriere, Lab Med Expt & Federat Neurol, Paris, France HopLa Pitie Salpetriere Paris France t & Federat Neurol, Paris, France
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 14, anno: 1999,
pagine: 230 - 236
SICI:
0885-3185(199903)14:2<230:CPAPDS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE GENE POLYMORPHISM; CYTOCHROME P4502D6; DRUG-METABOLISM; DEBRISOQUINE; POPULATION; FREQUENCIES; ALLELES; 2D6; PHENOTYPE; ASSOCIATION;
Keywords:
CYP2D6 polymorphism; SSCP; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Broly, F Ctr Hosp Reg & Univ Lille, Hop Calmette, Lab Biochim & Biol Mol, Bd Pr J Leclercq, F-59037 Lille, France Ctr Hosp Reg & Univ Lille Bd Pr J Leclercq Lille France F-59037
Citazione:
N. Sabbagh et al., "CYP2D6 polymorphism and Parkinson's disease susceptibility", MOVEMENT D, 14(2), 1999, pp. 230-236

Abstract

Following the recent identification of multiple novel mutations and alleles of the cytochrome P450 CYP2D6 gene which cause decreased, increased, or absent enzyme activity. we re-examined the controversial hypothesis of a role of the CYP2D6 polymorphism in Parkinson's disease (PD) susceptibility. For this purpose, a strategy based on PCR-SSCP and RFLP analyses allowing thedetection of all known CYP2D6 alleles was performed in DNA from 109 patients with sporadic PD. This strategy was also applied to DNA from 68 members of PD families including 18 affected and 50 unaffected members. Seventeen mutations occurring alone or in various combination on 14 alleles of CYP2D6 have been identified in patients with sporadic PD. Moreover, 12 mutations and nine alleles of the gene have been characterized in members of PD families. No significant difference was observed when the distribution of mutations and alleles of CYP2D6 was compared between the PD patients and 514 control subjects previously analyzed using the same strategy. There was also no difference in the distribution of phenotypes predicted from genotypes between both groups. In addition, when the distribution of CYP2D6 genotypes was compared, no difference between affected and unaffected members of PD families was observed. These data indicate that CYP2D6 polymorphism is not a susceptibility factor to PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:50:48