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Titolo:
Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells
Autore:
Jensen, CH; Erb, K; Westergaard, LG; Kliem, A; Teisner, B;
Indirizzi:
Odense Univ, Univ So Denmark, DK-5000 Odense C, Denmark Odense Univ Odense Denmark C Univ So Denmark, DK-5000 Odense C, Denmark Odense Univ Hosp, Fertil Clin, DK-5000 Odense, Denmark Odense Univ Hosp Odense Denmark DK-5000 il Clin, DK-5000 Odense, Denmark
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 10, volume: 5, anno: 1999,
pagine: 908 - 913
SICI:
1360-9947(199910)5:10<908:FA1AEM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING GENE-PRODUCT; GROWTH-HORMONE; ADIPOCYTE DIFFERENTIATION; AMNIOTIC-FLUID; PREF-1; EXPRESSION; PANCREAS; FA1; LOCALIZATION; SCP-1;
Keywords:
delta-like; EGF-superfamily; fetal antigen 1; follicular fluid; seminal plasma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Teisner, B Odense Univ, Univ So Denmark, Winslowpk 21-1, DK-5000 Odense C,Denmark Odense Univ Winslowpk 21-1 Odense Denmark C Odense C, Denmark
Citazione:
C.H. Jensen et al., "Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells", MOL HUM REP, 5(10), 1999, pp. 908-913

Abstract

Fetal antigen 1 (FA1), an epidermal growth factor (EGF) multidomain glycoprotein, was investigated in the human reproductive system. Immunohistochemical analysis of the male reproductive system revealed staining for FA1 in the Leydig cells only. Concentrations of FA1 in seminal plasma and serum were similar and significantly correlated in weekly samples from three men (P < 0.0065). The concentrations in seminal plasma from vasectomized men (n = 4) were not significantly different from those of normal men (n = 187). Theconcentration of FA1 in seminal plasma was significantly correlated with the sperm counts of normozoospermic men (P < 0.0001), and significantly higher in seminal plasma from men with sperm counts > 20 x 10(6)/ml, compared with those with counts less than or equal to 20 x 10(6)/ml (P < 0.0001). Immunohistochemical analysis of the ovary showed the presence of FA1 in the theca interna and the hilus cells hut not in the granulosa cells or the oocyte. In follicular fluid the concentration of FA1 (median; 73.3 ng/ml, n = 28) was three times higher than that of serum (median; 23.8 ng/ml). These data suggest a role for this novel member of the EGF superfamily in relation to human reproduction, but further experiments are needed to define the biological function and to elucidate its clinical potential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:16:22