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Titolo:
Regulation of selection of liver nodules initiated with N-nitrosodiethylamine and promoted with nodularin injections in Fischer 344 male rats by reciprocal expression of transforming growth factor-beta 1 and its receptors
Autore:
Lim, IK; Park, SC; Song, KY; Park, TJ; Lee, MS; Kim, SJ; Hyun, BH;
Indirizzi:
Ajou Univ, Sch Med, Dept Biochem & Mol Biol, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 & Mol Biol, Suwon 442749, South Korea Seoul Natl Univ, Coll Med, Dept Biochem, Seoul, South Korea Seoul Natl Univ Seoul South Korea Med, Dept Biochem, Seoul, South Korea Chung Ang Univ, Coll Med, Dept Pathol, Seoul 156756, South Korea Chung AngUniv Seoul South Korea 156756 athol, Seoul 156756, South Korea NCI, Lab Cell Regulat & Carcinogenesis, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 t & Carcinogenesis, NIH, Bethesda, MD 20892 USA Res Inst Biosci & Biotechnol, Yusong, South Korea Res Inst Biosci & Biotechnol Yusong South Korea ol, Yusong, South Korea
Titolo Testata:
MOLECULAR CARCINOGENESIS
fascicolo: 2, volume: 26, anno: 1999,
pagine: 83 - 92
SICI:
0899-1987(199910)26:2<83:ROSOLN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TGF-BETA RECEPTOR; HUMAN HEPATOCELLULAR-CARCINOMA; II RECEPTOR; KARYOTYPIC CHANGES; TUMOR PROMOTION; MESSENGER-RNA; CELLS; HEPATOCYTES; APOPTOSIS; GENES;
Keywords:
glutathione-s-transferase placental form; transforming growth factor-beta receptors; hepatocarcinogenesis; liver regeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lim, IK Ajou Univ, Sch Med, Dept Biochem & Mol Biol, Suwon 442749, South Korea Ajou Univ Suwon South Korea 442749 ol, Suwon 442749, South Korea
Citazione:
I.K. Lim et al., "Regulation of selection of liver nodules initiated with N-nitrosodiethylamine and promoted with nodularin injections in Fischer 344 male rats by reciprocal expression of transforming growth factor-beta 1 and its receptors", MOL CARCINO, 26(2), 1999, pp. 83-92

Abstract

To investigate how glutathione-s-transferase placental form (GST-P)+ hyperplastic nodules (HNs) are selected and to determine the driving force for progression or regression of HNs, changes in transforming growth factor-beta1 (TGF-beta) and its receptors were examined during hepatocarcinogenesis initiated by N-nitrosodiethylamine (DEN) and promoted by nodularin. The induction of TGF-beta 1 expression in the GST-P+ HNs was dependent on nodularininjections for 10 wk, which started the third week after DEN initiation. The kinetics of TGF-beta 1 induction during carcinogenesis were quite different from that of simple regeneration after partial hepatectomy (PH): hepatocytes initiated with DEN alone induced TGF-beta 1 expression for 24 d, and subsequent stimulation by PH on the fourteenth day after DEN initiation super-induced TGF-beta 1 mRNA (50 times that of the control level), as opposedto a transient expression for less than 5 d by PH alone. GST-P+ HNs did not express TGF-beta receptors I (RI) and II (RII) during the early stage of carcinogenesis, whereas the surrounding hepatocytes strongly expressed bothof these receptors. On cessation of nodularin injection, however, the expression of RI and RII in the HNs changed significantly: RII+ nodules appeared, and the number and area of RII+/- nodules were significantly increased at 10 wk after the cessation. These findings indicate that induction of TGF-beta expression in GST-P+ HNs might be a strong selection pressure that allows outgrowth of RII- nodules during liver carcinogenesis. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:19:43