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Titolo:
DNA strand breaks induced by ionizing radiation on Rubrobacter radiotolerans, an extremely radioresistant bacterium
Autore:
Terato, H; Kobayashi, M; Yamamoto, O; Ide, H;
Indirizzi:
Hiroshima Univ, Fac Sci, Grad Dept Gene Sci, Higashihiroshima 7398526, Japan Hiroshima Univ Higashihiroshima Japan 7398526 hihiroshima 7398526, Japan
Titolo Testata:
MICROBIOLOGICAL RESEARCH
fascicolo: 2, volume: 154, anno: 1999,
pagine: 173 - 178
SICI:
0944-5013(199909)154:2<173:DSBIBI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEINOCOCCUS-RADIODURANS; REPAIR;
Keywords:
Rubrobacter radiotolerans; radioresistance; DNA damage; radiation; free radical;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Terato, H Hiroshima Univ, Fac Sci, Grad Dept Gene Sci, Higashihiroshima 7398526, Japan Hiroshima Univ Higashihiroshima Japan 7398526 a 7398526, Japan
Citazione:
H. Terato et al., "DNA strand breaks induced by ionizing radiation on Rubrobacter radiotolerans, an extremely radioresistant bacterium", MICROBI RES, 154(2), 1999, pp. 173-178

Abstract

Rubrobacter radiotolerans is the most radioresistant bacterium showing 16 kGy as D-37 against gamma-rays. However mechanisms of the radioresistance have been still unclear. To clarify the post-irradiating events in the cell,we investigated DNA strand breaks which is the most major lesion induced by ionizing radiation. The neutral sucrose density gradient centrifugation analysis showed that size of the chromosomal DNA gradually decreased with irradiation dose. However, the frequency of DNA strand breaks after ionizing irradiation was significantly lower than those reported for other eubacteria. The reduced DNA sizes were not recovered during the post-irradiating cultivation. These results suggest that in this organism DNA protection from damage is mainly involved in the radioresistance, but not DNA repair activities.

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Documento generato il 22/09/20 alle ore 13:42:03