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Titolo:
Developmental changes in choline- and ethanolamine-containing compounds measured with proton-decoupled P-31 MRS in in vivo human brain
Autore:
Bluml, S; Seymour, KJ; Ross, BD;
Indirizzi:
Huntington Med Res Inst, Clin Magnet Resonance Spect Unit, Pasadena, CA 91105 USA Huntington Med Res Inst Pasadena CA USA 91105 nit, Pasadena, CA 91105 USA Rudi Schulte Res Inst, Santa Barbara, CA USA Rudi Schulte Res Inst Santa Barbara CA USA s Inst, Santa Barbara, CA USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 4, volume: 42, anno: 1999,
pagine: 643 - 654
SICI:
0740-3194(199910)42:4<643:DCICAE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-CALF-MUSCLE; NMR-SPECTROSCOPY; PHOSPHOLIPID-METABOLISM; ABSOLUTE QUANTITATION; RELAXATION-TIMES; H-1 MRS; INVIVO; RESONANCE; RAT; ENHANCEMENTS;
Keywords:
proton-decoupled P-31 MRS; ethanolamine; choline; myelination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bluml, S Huntington Med Res Inst, Clin Magnet Resonance Spect Unit, 660 S Fair OaksAve, Pasadena, CA 91105 USA Huntington Med Res Inst 660 S Fair Oaks Ave Pasadena CA USA 91105
Citazione:
S. Bluml et al., "Developmental changes in choline- and ethanolamine-containing compounds measured with proton-decoupled P-31 MRS in in vivo human brain", MAGN RES M, 42(4), 1999, pp. 643-654

Abstract

Cerebral phosphorylated metabolites, possibly involved in membrane and myelin sheath metabolism, were measured and quantified using proton-decoupled P-31 ({H-1}-P-31) MRS in 32 children and 28 adults. Age-dependent changes were determined for phosphorylethanolamine (PE), phosphorylcholine (PC), glycerophosphorylethanolamine (GPE), glycerophosphorylcholine (GPC), and phosphocreatine (PCr) concentrations. In the neonate, PE dominates the spectrum and decreases with age along with PC, whereas GPE, GPC, and PCr increase inconcentration with postnatal age. PE (1.23 +/- 0.13 mM) and GPE (0.57 +/- 0.08 mM) co-resonate with choline in H-1 MRS. Together with PC (0.57 +/- 0.12 mM) and GPC (0.94 +/- 0.13 mM) these four metabolites accounted for all of the visible H-1 MRS choline in normal adult brain. Children with diseases that affect myelination were found to have abnormal {H-1}-P-31 MRS. The new quantitative assay may provide novel insights in determining and monitoring normal and abnormal brain maturation noninvasively. Magn Reson Med 42:643-654, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:26:20