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Titolo:
Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy
Autore:
Taylor-Robinson, SD; Buckley, C; Changani, KK; Hodgson, HJF; Bell, JD;
Indirizzi:
Hammersmith Hosp, Imperial Coll Sch Med, Dept Med Med A, London W12 0NN, England Hammersmith Hosp London England W12 0NN d Med A, London W12 0NN, England MRC, Ctr Clin Sci, Robert Steiner NMR Unit, London W1N 4AL, England MRC London England W1N 4AL ert Steiner NMR Unit, London W1N 4AL, England
Titolo Testata:
LIVER
fascicolo: 5, volume: 19, anno: 1999,
pagine: 389 - 398
SICI:
0106-9543(199910)19:5<389:CPAPMR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL-SYSTEMIC ENCEPHALOPATHY; IN-VIVO; HUNTINGTONS-DISEASE; ELECTRON-MICROSCOPY; MR SPECTROSCOPY; CELL-FUNCTION; HUMAN LIVER; BRAIN; ABNORMALITIES; METABOLISM;
Keywords:
basal ganglia; glutamine; high energy phosphates; magnetic resonance spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor-Robinson, SD Hammersmith Hosp, Imperial Coll Sch Med, Dept Med Med A, Du Cane Rd, London W12 0NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN nd
Citazione:
S.D. Taylor-Robinson et al., "Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy", LIVER, 19(5), 1999, pp. 389-398

Abstract

Background/Aims: In vivo magnetic resonance spectroscopy can be used to study cerebral metabolism non-invasively. We aimed to correlate H-1 and P-31 magnetic resonance spectral abnormalities in the brains of patients with subclinical hepatic encephalopathy. Methods: Eighteen patients were studied at 1.5T, with combined H-1 and P-31 magnetic resonance spectra obtained frommultiple voxels in the cerebral cortex and basal ganglia. Peak area ratiosof choline, glutamine/glutamate, relative to creatine in the H-1 spectra and percentage phosphomonoesters, phosphodiesters and beta NTP signals relative to total P-31 signals in the P-31 spectra were measured. Results: Six patients did not complete the full examination - P-31 results are available from 12 patients only. Relative to creatine, there were reductions in choline and elevations in glutamine/glutamate, varying across the brain with choline significantly reduced in occipital cortex (p<0.05) and glutamine/glutamate most significantly elevated in temporo-parietal cortex (p<0.0001). Percentage phosphomonoester (p<0.05), phosphodiester (p<0.05) and beta NTP (p<0.005) signals were significantly decreased in basal ganglia spectra. No correlation was found between the magnitude of H-1 and P-31 MRS changes, except between percentage phosphodiester decrease and glutamine/glutamate to creatine increase in occipital cortex. Conclusion: The results of this study point to a multifactorial aetiology for this condition.

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Documento generato il 14/07/20 alle ore 02:48:47