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Titolo:
Osteoporosis, body composition, and bone turnover in ankylosing spondylitis
Autore:
El Maghraoui, A; Borderie, D; Cherruau, B; Edouard, R; Dougados, M; Roux, C;
Indirizzi:
Univ Paris 05, Cochin Hosp, Dept Rheumatol, F-75014 Paris, France Univ Paris 05 Paris France F-75014 Dept Rheumatol, F-75014 Paris, France Univ Paris 05, Cochin Hosp, Dept Biochem, F-75014 Paris, France Univ Paris05 Paris France F-75014 , Dept Biochem, F-75014 Paris, France
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 10, volume: 26, anno: 1999,
pagine: 2205 - 2209
SICI:
0315-162X(199910)26:10<2205:OBCABT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHEUMATOID-ARTHRITIS; DISEASE-ACTIVITY; MINERAL DENSITY; POSTMENOPAUSAL WOMEN; MASS; INDEX; BATH; ABSORPTIOMETRY; SCORE; AGE;
Keywords:
ankylosing spondylitis; bone mineral density; bone remodelling; osteoporosis; body composition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Roux, C Univ Paris 05, Cochin Hosp, Dept Rheumatol, 27 Rue Faubourg St Jacques, F-75014 Paris, France Univ Paris 05 27 Rue Faubourg St Jacques ParisFrance F-75014 nce
Citazione:
A. El Maghraoui et al., "Osteoporosis, body composition, and bone turnover in ankylosing spondylitis", J RHEUMATOL, 26(10), 1999, pp. 2205-2209

Abstract

Objective. To study the prevalence of osteoporosis (OP) and osteopenia in ankylosing spondylitis (AS) and to investigate the relationship between symptomatic and structural severity, the indices of bone turnover, and body composition. Methods. Eighty patients with AS were enrolled prospectively: 52 men (65%)and 25 women, mean age 36.7 years +/- 11.5 (range 18-67); they were studied clinically, radiologically, and by dual energy x-ray absorptiometry. Sixty-three underwent biological assessment of bone turnover markers. Results. OP and osteopenia as defined by the World Health Organization (T score < -2.5 SD and between -1 and -2.5 SD, respectively) were observed in 15 (18.7%) and 25 patients (31.2%) at the lumbar spine and in 11 (13.7%) and 33 patients (41.2%) at the femoral neck. respectively. Patients with OP had a lower body mass index (BMI) and fat mass percentage. There was a trendto a lower disease duration in patients with OP at the spine than in healthy subjects. Bone resorption markers (urinary D-pyridinoline or C-telopeptide concentrations) were increased in 34 patients (53.9%). Bone turnover markers were positively correlated with C-reactive protein concentration and Larsen radiological hip score: they were negatively correlated with Schober inder; and fat mass percentage. Conclusion. (1) OP is frequent in AS and can be observed in early stages of the disease. (2) Patients with AS are more susceptible to develop OP whenthey have low BMI. low fat mass percentage, and active and severe disease. OP was observed in parallel with increased bone resorption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:00:39