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Titolo:
Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12)in actinic damage
Autore:
Saarialho-Kere, U; Kerkela, E; Jeskanen, L; Hasan, T; Pierce, R; Starcher, B; Raudasoja, R; Ranki, A; Oikarinen, A; Vaalamo, M;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Dermatol, Helsinki 00250, Finland Univ Helsinki Helsinki Finland 00250 t Dermatol, Helsinki 00250, Finland Oulu Univ Hosp, Oulu, Finland Oulu Univ Hosp Oulu FinlandOulu Univ Hosp, Oulu, Finland Tampere Univ, Cent Hosp, SF-33520 Tampere, Finland Tampere Univ Tampere Finland SF-33520 nt Hosp, SF-33520 Tampere, Finland Washington Univ, Sch Med, Barnes Jewish Hosp, Div Dermatol, St Louis, MO USA Washington Univ St Louis MO USA ish Hosp, Div Dermatol, St Louis, MO USA Univ Texas, Ctr Hlth, Dept Biochem, Tyler, TX 75710 USA Univ Texas Tyler TX USA 75710 Ctr Hlth, Dept Biochem, Tyler, TX 75710 USA
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 4, volume: 113, anno: 1999,
pagine: 664 - 672
SICI:
0022-202X(199910)113:4<664:AOM(AM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX METALLOPROTEINASE; GENE-EXPRESSION; CHROMOSOMAL LOCATION; HAIRLESS MICE; IN-VIVO; SKIN; COLLAGENASE; ELASTIN; DERMIS; IDENTIFICATION;
Keywords:
elastin; keratosis; tenascin; versican;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Saarialho-Kere, U Univ Helsinki, Cent Hosp, Dept Dermatol, Meilahdentie 2,Helsinki 00250, Finland Univ Helsinki Meilahdentie 2 Helsinki Finland 00250 and
Citazione:
U. Saarialho-Kere et al., "Accumulation of matrilysin (MMP-7) and macrophage metalloelastase (MMP-12)in actinic damage", J INVES DER, 113(4), 1999, pp. 664-672

Abstract

Photodamage is characterized by degradation of collagen and accumulation of abnormal elastin in the superficial dermis and several matrix metalloproteinases have previously been implicated in this process. Using immunohistochemistry and in situ hybridization, we have studied the localization of twoelastolytic matrix metalloproteinases, matrilysin (matrix metalloproteinase-7) and human macrophage metalloelastase (matrix metalloproteinase-12) in solar damage. Human macrophage metalloelastase protein was detected in the superficial dermis in areas of elastotic material. Matrix metalloproteinase-7 was seen in the mid-dermis in regions with less damaged elastic fibers and morphologically better preserved collagen as well as in a band-like pattern below basal keratinocytes in eight of 18 solar elastosis. In samples taken from healthy volunteers 3 d after repeated ultraviolet A or ultravioletB photoprovocation, occasional immunopositive cells for human macrophage metalloelastase (stromal) or matrix metanoproteinase-7 (sweat gland epithelium) were detected. In samples taken 1 d after ultraviolet B exposure, however, basal keratinocytes were matrix metalloproteinase-7 immunopositive, explaining the linear immunostaining below basal keratinocytes noted particularly in ultraviolet B treated 3 d specimens. Upregulation of metalloelastasewas also demonstrated in the skin of hairless mice after repeated ultraviolet exposure. In normal skin, no staining for human macrophage metalloelastase or matrix metalloproteinase-7 was observed in association with elastin. The amount of immunoreactivity for the substrates of matrix metalloproteinase-7, versican, and tenascin, was clearly increased in solar elastosis andphotoprovocated skin; versican but not tenascin was detected in the same areas as matrix metalloproteinase-7. Our results suggest that both matrix metalloproteinase-7 and -12 may contribute to remodeling of elastotic areas in sun-damaged skin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:05:18