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Titolo:
Differences in aortic response to vasoactive stimuli in Japanese and Lyon rats. The role of hypertension
Autore:
Chamiot-Clerc, P; Legrand, M; Sassard, J; Safar, ME; Renaud, JF;
Indirizzi:
Hop Broussais, Dept Internal Med, F-75674 Paris 14, France Hop Broussais Paris France 14 ept Internal Med, F-75674 Paris 14, France Hop Broussais, INSERM, U337, F-75674 Paris, France Hop Broussais Paris France F-75674 , INSERM, U337, F-75674 Paris, France Hop Marie Lannelongue, CNRS, ESA 8078, F-92350 Le Plessis Robinson, FranceHop Marie Lannelongue Le Plessis Robinson France F-92350 obinson, France Univ Lyon 1, CNRS, ESA 5014, F-69365 Lyon, France Univ Lyon 1 Lyon France F-69365 1, CNRS, ESA 5014, F-69365 Lyon, France
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 10, volume: 17, anno: 1999,
pagine: 1403 - 1411
SICI:
0263-6352(199910)17:10<1403:DIARTV>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT CONTRACTIONS; VASCULAR SMOOTH-MUSCLE; RENIN-ANGIOTENSIN SYSTEM; L-ARGININE; CELLULAR BIOLOGY; BLOOD-PRESSURE; ACETYLCHOLINE; CELLS; NOREPINEPHRINE;
Keywords:
genetic hypertension in rats; vasoreactivity of conduit arteries; endothelium function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Safar, ME Hop Broussais, Dept Internal Med, 96 Rue Didot, F-75674 Paris 14, France Hop Broussais 96 Rue Didot Paris France 14 674 Paris 14, France
Citazione:
P. Chamiot-Clerc et al., "Differences in aortic response to vasoactive stimuli in Japanese and Lyon rats. The role of hypertension", J HYPERTENS, 17(10), 1999, pp. 1403-1411

Abstract

Objective We have previously shown that conduit arteries of normotensive (WKY) and hypertensive (SHR) Japanese rats differ from normotensive (LN) andhypertensive (LH) Lyon rats in terms of lower aortic thickness and higher collagen III content, whereas differences in vasoactive properties are unknown. Methods Aortic rings with (E+) and without (E-) endothelium were studied under resting and noradrenaline-stimulated conditions in the presence of N omega-nitro-L-arginine (L-NNA) alone or in association with indomethacin, bosentan and/or BQ123. Results Under resting conditions, aortas of normotensive and hypertensive Japanese rats differed from Lyon rats by higher developed tension in the presence of L-NNA and endothelium. In the absence of endothelium, normotensives differed from hypertensives in terms of stronger developed tensions in the presence of L-NNA in the two strains. Addition of indomethacin to L-NNA induced relaxation in E+ SHR and E- WKY and contraction in ELH. By contrast, tensions were unchanged after addition of bosentan and BQ123. Under stimulated conditions, tensions were equally increased by L-NNA in E+ and unchanged in E- both in Japanese and Lyon rats whether they were normotensive or hypertensive, and indomethacin (but not bosentan) elicited higher response in Lyon than in Japanese rats in E+ and E- aorta. Conclusion Under NO synthase inhibition, the vasoactive properties of Japanese and Lyon aorta differ in the presence of a cyclo-oxygenase blocker butnot endothelin blockers. These results indicate that the aorta vasorelaxant tone is associated to prostanoid regulation in Lyon but not in Japanese rats. This observation appears dependent on the genetic and/or environmentalbackground linked to the origin and not the presence of hypertension. J Hypertens 1999, 17:1403-1411 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:13:51