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Titolo:
Synthesis of piperidine analogs of 1-(3-chlorophenyl)piperazine, a well known serotonin ligand
Autore:
Radl, S; Hezky, P; Taimr, J; Proska, J; Krejci, I;
Indirizzi:
Res Inst Pharm & Biochem, CR-13060 Prague, Czech Republic Res Inst Pharm &Biochem Prague Czech Republic CR-13060 , Czech Republic
Titolo Testata:
JOURNAL OF HETEROCYCLIC CHEMISTRY
fascicolo: 4, volume: 36, anno: 1999,
pagine: 1017 - 1022
SICI:
0022-152X(199907/08)36:4<1017:SOPAO1>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST; ANPIRTOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Radl, S Res Inst Pharm & Biochem, Kourimska 17, CR-13060 Prague, Czech Republic Res Inst Pharm & Biochem Kourimska 17 Prague Czech Republic CR-13060
Citazione:
S. Radl et al., "Synthesis of piperidine analogs of 1-(3-chlorophenyl)piperazine, a well known serotonin ligand", J HETERO CH, 36(4), 1999, pp. 1017-1022

Abstract

Synthesis of arylpiperideines 3a-3d and arylpiperidines 4a-4d as analogs of a well known serotonin ligand 1-(3-chlorophenyl)piperazine is reported. Starting aryllithium derivatives were treated with 1-methyl-piperdin-4-one to provide the corresponding hydroxy derivatives 6a and 6b. N-Methylpiperideine derivatives 3a and 3c were obtained by their dehydration while the corresponding N-unsubstituted compounds 3b and 3d were prepared indirectly by athree-step procedure. Hydrogenation of piperideine 3a provided the corresponding piperidine derivative 4a which after demethylation yielded 4b. Similar 4-pyridyl derivatives 4c and 4d were prepared by a similar strategy via the corresponding methoxy derivatives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:10:45