Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
delta-catenin, an adhesive junction-associated protein which promotes cellscattering
Autore:
Lu, Q; Paredes, M; Medina, M; Zhou, JH; Cavallo, R; Peifer, M; Orecchio, L; Kosik, KS;
Indirizzi:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis,Dept Neurol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ol Dis,Dept Neurol, Boston, MA 02115 USA Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Biol, Chapel Hill, NC 27599 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 3, volume: 144, anno: 1999,
pagine: 519 - 532
SICI:
0021-9525(19990208)144:3<519:DAAJPW>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE SUBSTRATE; POLYPOSIS-COLI PROTEIN; BETA-CATENIN; E-CADHERIN; CYTOPLASMIC DOMAIN; ALPHA-CATENIN; DESMOSOMAL PLAQUE; FAMILY MEMBER; APC PROTEIN; COMPLEX;
Keywords:
delta-catenin; armadillo; adhesive junctions; cell motility; neural development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kosik, KS Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis,Dept Neurol, 77 Ave Louis Pasteur, Boston, MA 02115 USA Harvard Univ 77 Ave Louis Pasteur Boston MA USA 02115 02115 USA
Citazione:
Q. Lu et al., "delta-catenin, an adhesive junction-associated protein which promotes cellscattering", J CELL BIOL, 144(3), 1999, pp. 519-532

Abstract

The classical adherens junction that holds epithelial cells together consists of a protein complex in which members of the cadherin family linked to various catenins are the principal components. delta-catenin is a mammalianbrain protein in the Armadillo repeat superfamily with sequence similarityto the adherens junction protein p120(ctn). We found that delta-catenin can be immunoprecipitated as a complex with other components of the adherens junction, including cadherin and beta-catenin, from transfected cells and brain. The interaction with cadherin involves direct contact within the highly conserved juxtamembrane region of the COOH terminus, where p120(ctn) also binds. In developing mouse brain, staining with delta-catenin antibodies is prominent towards the apical boundary of the neuroepithelial cells in the ventricular zone. When transfected into Madin-Darby canine kidney (MDCK) epithelial cells delta-catenin colocalized with cadherin, p120(ctn), and beta-catenin. The Arm domain alone was sufficient for achieving localization and coimmunoprecipitation with cadherin. The ectopic expression of delta-catenin in MDCK cells altered their morphology, induced the elaboration of lamellipodia, interfered with monolayer formation, and increased scattering in response to hepatocyte growth factor treatment. We propose that delta-catenin can regulate adhesion molecules to implement the organization of largecellular arrays necessary for tissue morphogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:13:59