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Titolo:
IN-VITRO STUDY USING LEUKEMIA-CELL LINE PANEL TO DEMONSTRATE RAPID THYMIC T-CELL DEATH DUE TO CONTACT WITH HIV-1 CARRIER CELL CLONES
Autore:
MINOWADA J; NISHIZAKI C; TOKI M; KINZL P; OTANI T; MATSUO Y;
Indirizzi:
HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR,675-1 FUJISAKI OKAYAMA702 JAPAN
Titolo Testata:
Leukemia
fascicolo: 5, volume: 11, anno: 1997,
pagine: 714 - 722
SICI:
0887-6924(1997)11:5<714:ISULLP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; SCID-HU MOUSE; PROGENITOR CELLS; LYMPHOID-TISSUE; INFECTED-CELLS; FLOW-CYTOMETRY; LYMPHOCYTES-T; APOPTOSIS; REPLICATION; THYMOCYTES;
Keywords:
THYMIC T CELL DEATH; HIV-1 CARRIER; LEUKEMIA CELL LINE; RAPID CYTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Minowada et al., "IN-VITRO STUDY USING LEUKEMIA-CELL LINE PANEL TO DEMONSTRATE RAPID THYMIC T-CELL DEATH DUE TO CONTACT WITH HIV-1 CARRIER CELL CLONES", Leukemia, 11(5), 1997, pp. 714-722

Abstract

A rapid (within 1 h) and profound cytotoxic cell death of immature TdT(+)CD4(+)CD8(+) and/or TdT(+)CD4(+) thymic T cell type leukemia cell lines, and of normal thymocyte populations rich in TdT(+)CD4(+)CD8(+) cells was induced by contact with some human immunodeficiency virus type-1 (HIV-1) carrier T cell clones. This cytotoxic reaction, without requiring a complete viral replication cycle in the thymic T cells, didnot occur in any mature CD4(+)CD8(+) and/or CD4(+) T cells which are otherwise permissive for virus infection. Although it was not an antigen-specific cytotoxic reaction, the rapid and profound thymic T cell destruction was shown, at the individual clonal level, to be triggered specifically by the binding of CD4 molecules on thymic T cells with gp120/gp160 on HIV-1 carrier clones. The present study suggesting directelimination of immature T cells by contact with some HlV-1-infected Tcells, may provide a novel insight into the mechanism responsible forthe mature CD4(+) T cell depletion in HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:51:46