Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIPARKINSONIAN AND OTHER MOTOR EFFECTS OF FLUPIRTINE ALONE AND IN COMBINATION WITH DOPAMINERGIC DRUGS
Autore:
SCHMIDT WJ; SCHUSTER G; WACKER E; PERGANDE G;
Indirizzi:
UNIV TUBINGEN,INST ZOOL,DEPT NEUROPHARMACOL,MOHLSTR 54-1 D-72074 TUBINGEN GERMANY ASTA MED AG,DEPT MED NEUROL D-60314 FRANKFURT GERMANY
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 327, anno: 1997,
pagine: 1 - 9
SICI:
0014-2999(1997)327:1<1:AAOMEO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NMDA RECEPTOR ANTAGONISTS; PARKINSONS-DISEASE; INDUCED CATALEPSY; ANIMAL-MODELS; RATS; SCHIZOPHRENIA; AMPHETAMINE; HALOPERIDOL; GYKI-52466;
Keywords:
FLUPIRTINE; NMDA RECEPTOR, ANTAGONISTIC; CATALEPSY; LOCOMOTION; L-DOPA (L-DIHYDROXYPHENYLALANINE); PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
W.J. Schmidt et al., "ANTIPARKINSONIAN AND OTHER MOTOR EFFECTS OF FLUPIRTINE ALONE AND IN COMBINATION WITH DOPAMINERGIC DRUGS", European journal of pharmacology, 327(1), 1997, pp. 1-9

Abstract

In this study we attempted to specify the behavioural profile of the analgesic flupirtine (1, 10 and 20 mg/kg p.o.) in the rat with respectto (i) its antiparkinsonian potential alone and as an adjunct to L-dihydroxyphenylalanine (L-DOPA) in the haloperidol-induced catalepsy (0.5 mg/kg haloperidol i.p.), (ii) locomotion and exploratory behaviour in the open field with holeboard, and (iii) possible psychomotor stimulating effects in the experimental chamber. In the two latter tests, behaviour was additionally challenged by D-amphetamine (2 mg/kg i.p.). In the catalepsy tests (horizontal bar, podium, grid) flupirtine alone was anticataleptic at doses of 10 and 20 mg/kg p.o., and the antiparkinsonian potential of a subthreshold dose of L-DOPA (50 mg/kg p.o.) waspotentiated by 1 and 10 mg/kg p.o. flupirtine. On spontaneous forwardlocomotion in the open field with holeboard flupirtine (1 and 10 mg/kg p.o.) had no marked effect but increased the frequency and duration of head dips, indicative for augmenting exploratory behaviour. Spontaneous rearing was reduced and D-amphetamine-induced rearing was enhanced by 1 mg/kg p.o. flupirtine. Grooming was reduced by 1 and 10 mg/kg p.o. flupirtine. In contrast, turning and grooming behaviour (spontaneous as well as D-amphetamine-induced) was not markedly influenced by flupirtine in the experimental chamber. Sniffing was increased in this test by 1 mg/kg p.o. flupirtine but not by the higher dose. Flupirtine is highly effective in antagonising neuroleptic-induced catalepsy as well as in potentiating L-DOPA treatment in the rat, suggesting it is aprospective new candidate for the therapy of Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:48:22