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Titolo:
Telomerase activity correlates with histo-pathological factors in uterine endometrial carcinoma
Autore:
Ebina, Y; Yamada, H; Fujino, T; Furuta, I; Sakuragi, N; Yamamoto, R; Katoh, M; Oshimura, M; Fujimoto, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 Ku, Sapporo, Hokkaido 060, Japan Tottori Univ, Fac Med, Sch Life Sci, Dept Mol & Cell Genet, Yonago, Tottori 683, Japan Tottori Univ Yonago Tottori Japan 683 l Genet, Yonago, Tottori 683, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 5, volume: 84, anno: 1999,
pagine: 529 - 532
SICI:
0020-7136(19991022)84:5<529:TACWHF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE REPRODUCTIVE-TRACT; CANCER; ACTIVATION; NEOPLASMS; MUTATIONS; TUMORS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Ebina, Y Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, N15 W7, Sapporo, Hokkaido 060, Japan Hokkaido Univ N15 W7 Sapporo Hokkaido Japan 060kkaido 060, Japan
Citazione:
Y. Ebina et al., "Telomerase activity correlates with histo-pathological factors in uterine endometrial carcinoma", INT J CANC, 84(5), 1999, pp. 529-532

Abstract

Telomerase activity has been implicated in the progression of various human tumors. Our aim was to evaluate telomerase activity and to compare it with histo-pathological factors in uterine endometrial carcinoma, to look for possible correlations. Telomerase activity was measured by dilution analysis using a PCR-based telomeric repeat amplification method and detected in 31 of 35 primary endometrial carcinoma tumor specimens. High telomerase activity, detected after 100-fold dilution of extracts, was identified in 15 specimens. There was no significant correlation between the positive telomerase activity and tumor surgical stage or histopathological factors. However,high telomerase activity was significantly correlated with advanced surgical stage and with pelvic lymph node metastasis. Our findings suggest that an increase in telomerase activity may be associated with tumor progression and that its level may have a prognostic value in endometrial carcinoma. Int. J. Cancer (Pred. Oncol.) 84:529-532, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:53:25