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Titolo:
Vulnerability of the gerbil cochlea to sound exposure during reversible ischemia
Autore:
Mom, T; Bonfils, P; Gilain, L; Avan, P;
Indirizzi:
Univ Auvergne, Fac Med, Lab Biophys Sensorielle, EA 2667, F-63001 ClermontFerrand, France Univ Auvergne Clermont Ferrand France F-63001 01 ClermontFerrand, France UPRESA CNRS 7060, Paris, France UPRESA CNRS 7060 Paris FranceUPRESA CNRS 7060, Paris, France
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 136, anno: 1999,
pagine: 65 - 74
SICI:
0378-5955(199910)136:1-2<65:VOTGCT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRODUCT OTOACOUSTIC EMISSIONS; ACOUSTIC DISTORTION PRODUCTS; LASER-DOPPLER MEASUREMENTS; GUINEA-PIG COCHLEA; FOREBRAIN ISCHEMIA; BLOOD-FLOW; TRANSIENT ISCHEMIA; NEUROMA SURGERY; THRESHOLD SHIFT; ACTIVE PROCESS;
Keywords:
noise-induced hearing loss; distortion-product otoacoustic emission; cochlear blood flow; ischemia; reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Avan, P Univ Auvergne, Fac Med, Lab Biophys Sensorielle, EA 2667, POB 38, F-63001 Clermont Ferrand, France Univ Auvergne POB 38 Clermont Ferrand France F-63001 rand, France
Citazione:
T. Mom et al., "Vulnerability of the gerbil cochlea to sound exposure during reversible ischemia", HEARING RES, 136(1-2), 1999, pp. 65-74

Abstract

Cochlear ischemia induces a sensorineural hearing loss, in part through a fast functional impairment of outer hair cellls. Assuming that the cochlea is rendered fragile during ischemia and reperfusion and that stimulation itself can jeopardize its functional recovery, we used a model of reversible selective cochlear ischemia in Mongolian gerbils to establish what type of sound exposure call be deleterious during and immediately after reversible ischemia. Several groups of gerbils were used, with different ischemia durations and levels of sound exposure. Control groups were only exposed to tones at 80 and 90 dB SPL during 30 min, while other groups underwent completeand fully reversible blockage of the labyrinthine artery, during 5.5 or 8 min, and were exposed to 60 or SO dB SPL tones during 30 min. The amount ofischemia and reperfusion was measured by means of laser Doppler velocimetry, whereas outer hair cells' function was continuously monitored through distortion-product otoacoustic emissions (DPOAEs). The losses of DPOAE levelsafter 8 min transient ischemia and 60 dB SPL exposure were as large as those induced by 80 dB SPL exposures combined with 5.5 min ischemia, or 90 dB SPL exposures without ischemia, with a maximum loss around 25-30 dB, half an octave above the stimulus frequency. These results give evidence for an extremely high cochlear vulnerability to low-level sound exposure when associated with reversible ischemia. This vulnerability may have important clinical consequences in patients with cochlear circulatory disturbances. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/10/20 alle ore 03:21:58