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Titolo:
Use of acarbose for eliminating the interval between meal consumption and insulin injection in patients with Type 1 diabetes
Autore:
Koch, HH; Wudy, A; Eberlein, G; Quast, C;
Indirizzi:
Klinikum Nurnberg, Med Klin 1, D-90340 Nurnberg, Germany Klinikum Nurnberg Nurnberg Germany D-90340 1, D-90340 Nurnberg, Germany
Titolo Testata:
DIABETES NUTRITION & METABOLISM
fascicolo: 3, volume: 12, anno: 1999,
pagine: 195 - 201
SICI:
0394-3402(199906)12:3<195:UOAFET>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Keywords:
Type 1 diabetes; insulin; injection-meal interval;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Koch, HH Klinikum Nurnberg, Med Klin 1, Flurstr 7, D-90340 Nurnberg, Germany Klinikum Nurnberg Flurstr 7 Nurnberg Germany D-90340 rg, Germany
Citazione:
H.H. Koch et al., "Use of acarbose for eliminating the interval between meal consumption and insulin injection in patients with Type 1 diabetes", DIABET NUTR, 12(3), 1999, pp. 195-201

Abstract

This double-blind, placebo-controlled, cross-over study investigated whether acarbose therapy enables patients with Type 1 diabetes to administer insulin injections at the same time as meals without adverse glycaemic consequences, thus negating the need for an injection-meal interval (IMI), The valid-case population was 15, All patients were well controlled on insulin therapy and diet, Each patient underwent four 14-d treatment sequences: IMI of0 min+acarbose; IMI of 30 min + acarbose; IMI of 0 min + placebo; IMI of 30 min + placebo. There was a 1-wk, placebo-controlled washout period between each treatment. A 50 mg acarbose or placebo tablet was taken with each ofthree meals for the first 3 d of each treatment; this was increased to 100mg three times daily on the remaining 11 d, Blood samples were taken between 08.00 and 09.00 h at the end of each treatment sequence, during the fasting state and at the following times after breakfast: 30, 60, 120 and 180 min, The primary target variable was 1-hr postprandial blood glucose level after 14 d, The mean increase in 1-hr postprandial blood glucose level usingan IMI of 0 min + acarbose was 51.1+/-53.2 mg/dl, compared with 46.6+/-50.4 mg/dl using a 30-min IMI + placebo, Data provided strong evidence that acarbose prevents the marked increase in postprandial glucose level normally observed when insulin is administered with a meal, Acarbose may thus be useful for patients with Type 1 diabetes who find IMIs inconvenient. (C) 1999,Editrice Kurtis.

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Documento generato il 01/10/20 alle ore 02:54:20