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Titolo:
In vivo prediction of vascular susceptibility to vascular endothelial growth factor withdrawal: Magnetic resonance imaging of C6 rat glioma in nude mice
Autore:
Abramovitch, R; Dafni, H; Smouha, E; Benjamin, LE; Neeman, M;
Indirizzi:
Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 Biol, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Mol Biol, IL-91010 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91010 -91010 Jerusalem, Israel
Titolo Testata:
CANCER RESEARCH
fascicolo: 19, volume: 59, anno: 1999,
pagine: 5012 - 5016
SICI:
0008-5472(19991001)59:19<5012:IVPOVS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-VESSEL; TISSUE FACTOR; ANGIOGENESIS; TUMORS; EXPRESSION; RECEPTOR; CELLS; ANGIOPOIETIN-1; HYPEROXIA; PERICYTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Neeman, M Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 6100 Rehovot, Israel
Citazione:
R. Abramovitch et al., "In vivo prediction of vascular susceptibility to vascular endothelial growth factor withdrawal: Magnetic resonance imaging of C6 rat glioma in nude mice", CANCER RES, 59(19), 1999, pp. 5012-5016

Abstract

One of the hallmarks of tumor neovasculature is the prevalence of immaturevessels manifested by the low degree of recruitment of vascular mural cells such as pericytes and smooth muscle cells. This difference in the architecture of the vascular bed provides an important therapeutic window for inflicting tumor-selective vascular damage. Here we demonstrate the applicationof gradient echo magnetic resonance imaging (MRI) for noninvasive in vivo mapping of vascular maturation, manifested by the ability of mature vesselsto dilate in response to elevated levels of CO2. Histological alpha-actin staining showed a match between dilating vessels detected by MRI and vessels coated with smooth muscle cells. Switchable, vascular endothelial growth factor (VEGF)-overexpressing tumors (C6-pTET-VEGF rat glioma s.c, tumors innude mice) displayed high vascular function and significant vascular damage upon VEGF withdrawal. However, damage was restricted to nondilating vessels, whereas mature dilating tumor vessels were resistant to VEGF withdrawal. Thus, MRI provides in vivo visualization of vascular maturity and prognosis of vascular obliteration induced by VEGF withdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:46:50