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Titolo:
Selective MHC expression in tumours modulates adaptive and innate antitumour responses
Autore:
Rees, RC; Mian, S;
Indirizzi:
Nottingham Trent Univ, Dept Life Sci, Nottingham NG11 8NS, England Nottingham Trent Univ Nottingham England NG11 8NS gham NG11 8NS, England
Titolo Testata:
CANCER IMMUNOLOGY IMMUNOTHERAPY
fascicolo: 7, volume: 48, anno: 1999,
pagine: 374 - 381
SICI:
0340-7004(199910)48:7<374:SMEITM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA-CLASS-I; NATURAL-KILLER-CELLS; EPSTEIN-BARR-VIRUS; COMPLEX CLASS-I; CYTOLYTIC T-LYMPHOCYTES; DR ANTIGEN EXPRESSION; NECROSIS-FACTOR-ALPHA; IFN-GAMMA; INHIBITORY RECEPTORS; HISTOCOMPATIBILITY ANTIGEN;
Keywords:
tumour escape; T cells; natural killer cells; killer cell inhibitory receptors; major histocompatibility complex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Rees, RC Nottingham Trent Univ, Dept Life Sci, Clifton Lane, Nottingham NG11 8NS, England Nottingham Trent Univ Clifton Lane Nottingham England NG118NS d
Citazione:
R.C. Rees e S. Mian, "Selective MHC expression in tumours modulates adaptive and innate antitumour responses", CANCER IMMU, 48(7), 1999, pp. 374-381

Abstract

Progress towards developing vaccines that can stimulate an immune responseagainst growing tumours has involved the identification of the protein antigens associated with a given tumour type. Epitope mapping of tumour antigens for HLA class I- and class II-restricted binding motifs followed by immunization with these peptides has induced protective immunity in murine models against cancers expressing the antigen. MHC class I molecules presentingthe appropriate peptides are necessary to provide the specific signals forrecognition and killing by cytotoxic T cells (CTL). The principle mechanism of tumour escape is the loss, downregulation or alteration of HLA profiles that may render the target cell resistant to CTL lysis, even if the cell expresses the appropriate tumour antigen. In human tumours HLA loss may be as high as 50%, inferring that a reduction in protein levels might offer a survival advantage to the tumour cells. Alternatively, MHC loss may render tumour cells susceptible to natural killer cell-mediated lysis because theyare known to act as ligands for killer inhibitory receptors (KIRs). We review the molecular features of MHC class I and class II antigens and discusshow surface MHC expression may be regulated upon cellular transformation. In addition, selective loss of MHC molecules may alter target tumour cell susceptibility to lymphocyte killing. The development of clinical immunotherapy will need to consider not only the expression of relevant CTL target MHC proteins, but also HLA inhibitory to NK and T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:45:28