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Titolo:
Function and dysfunction of CD4(+) T cells in the immune response to melanoma
Autore:
Fischer, WH; Straten, PT; Terheyden, P; Becker, JC;
Indirizzi:
Univ Wurzburg, Dept Dermatol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 rmatol, D-97080 Wurzburg, Germany Danish Canc Soc, Dept Tumor Cell Biol, Copenhagen, Denmark Danish Canc Soc Copenhagen Denmark Tumor Cell Biol, Copenhagen, Denmark Univ Wurzburg, Dept Immunotoxicol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 oxicol, D-97080 Wurzburg, Germany
Titolo Testata:
CANCER IMMUNOLOGY IMMUNOTHERAPY
fascicolo: 7, volume: 48, anno: 1999,
pagine: 363 - 370
SICI:
0340-7004(199910)48:7<363:FADOCT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; CYTOKINE MESSENGER-RNA; IN-VITRO; CROSS-PRESENTATION; DENDRITIC CELLS; SPONTANEOUS REGRESSION; RESTRICTED RESPONSES; ANTIGEN PRESENTATION; METASTATIC MELANOMA; SIGNAL-TRANSDUCTION;
Keywords:
CD4; MHC class II; T-cell dysfunction; melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, JC Univ Wurzburg, Dept Dermatol, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 y
Citazione:
W.H. Fischer et al., "Function and dysfunction of CD4(+) T cells in the immune response to melanoma", CANCER IMMU, 48(7), 1999, pp. 363-370

Abstract

A major difficulty for tumor immunotherapy derives from the phenomenon that the encounter of the immune system with an antigen does not necessarily result in activation, but may also be followed by the induction of toleranceeither by anergy or physical deletion. It is well established that the immune system becomes alerted only in the face of danger, i.e. upon ligand recognition in the context of increased expression of costimulatory molecules,adhesion molecules, and MHC molecules on antigen-presenting cells (APC). The pivotal role of CD4(+) T lymphocytes in this process has been established. However, encounter of CD4(+) T cells with either MHC class II-expressingmelanoma cells or certain tumor antigen-presenting APC has been reported to induce antigen-specific tolerance. Thus, as more is learned about the molecular regulation of immune responses and the role of CD4(+) T cells in particular, additional strategies to block inhibitory pathways of T-cell activation will be developed. Such strategies are likely to be based on a modulation of the context in which antigen is encountered by the immune system, e.g. in situ cytokine therapy, induction of costimulatory molecules or the simulation of 'danger' signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:57:00