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Titolo:
Mode of exocrine pancreatic function and regulation in pigs at weaning
Autore:
Pierzynowski, SG; Rehfeld, JF; Olsen, O; Karlsson, S; Ahren, B; Podgurniak, M; Karlsson, BW; Westrom, BR;
Indirizzi:
Univ Lund, Dept Anim Physiol, SE-22362 Lund, Sweden Univ Lund Lund Sweden SE-22362 Dept Anim Physiol, SE-22362 Lund, Sweden
Titolo Testata:
BIOLOGY OF THE PANCREAS IN GROWING ANIMALS
, volume: 28, anno: 1999,
pagine: 231 - 248
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ-OCTAPEPTIDE; RECEPTOR ANTAGONIST; ENZYME-ACTIVITIES; CONSCIOUS PIG; LONG-TERM; SECRETION; GROWTH; STIMULATION; INSULIN; RATS;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Pierzynowski, SG Univ Lund, Dept Anim Physiol, Helgonavagen 3B, SE-22362 Lund, Sweden Univ Lund Helgonavagen 3B Lund Sweden SE-22362 d, Sweden
Citazione:
S.G. Pierzynowski et al., "Mode of exocrine pancreatic function and regulation in pigs at weaning", DEV AN VET, 28, 1999, pp. 231-248

Abstract

The development of the mechanisms regulating pancreatic functions are still largely unknown. In an attempt to address this issue the development of the enteropancreatic reflexes regulating pancreatic secretion were followed by measuring the blood plasma levels of some essential GI hormones in youngpigs from 3 weeks of age and up to a few weeks after weaning. Exogenous secretin stimulated the exocrine pancreas before weaning, while only a slight increase in trypsin output occurred after exogenous CCK administration before weaning. The exocrine pancreas did not response to intraduodenal (id) stimulation with intact protein, amino acids or lipid, indicating that mechanisms regulating the exocrine pancreas that are based on enteropancreatic reflexes evoked by protein and fat either do not exist or are not fully developed before and directly after weaning. Moreover, the lack ofany stimulation of pancreatic secretion by duodenal acidification suggeststhat the HCl-dependent enteropancreatic reflex does not function in pigs at the age studied. However, the increasing stimulation of pancreatic protein output seen with id infusion of oleic acid in the oldest post weaning pigs studied indicates that the stimulation of enteropancreatic reflexes evoked by fatty acids in young pigs is brought on by weaning. The changes observed in the basal level of GI tract hormones in the blood plasma, i.e., decreased basal plasma CCK, glucagon and somatostatin levels and increased secretin and insulin levels can be related to increased pancreatic secretion around weaning.

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Documento generato il 19/09/20 alle ore 08:24:32