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Titolo:
Probability description of ligand-receptor interactions. Evaluation of reliability of events with small and supersmall doses. I. Kinetics of ligand-receptor interactions
Autore:
Gurevich, KG; Varfolomeev, SD;
Indirizzi:
Moscow MV Lomonosov State Univ, Sch Chem, Dept Chem Enzymol, Moscow 119899, Russia Moscow MV Lomonosov State Univ Moscow Russia 119899 oscow 119899, Russia
Titolo Testata:
BIOCHEMISTRY-MOSCOW
fascicolo: 9, volume: 64, anno: 1999,
pagine: 1038 - 1048
SICI:
0006-2979(199909)64:9<1038:PDOLIE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING; NALOXONE; VITRO;
Keywords:
ligand-receptor interaction; Markov chains; small and supersmall doses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Gurevich, KG Moscow MV Lomonosov State Univ, Sch Chem, Dept Chem Enzymol, Moscow 119899, Russia Moscow MV Lomonosov State Univ Moscow Russia 119899 Russia
Citazione:
K.G. Gurevich e S.D. Varfolomeev, "Probability description of ligand-receptor interactions. Evaluation of reliability of events with small and supersmall doses. I. Kinetics of ligand-receptor interactions", BIOCHEM-MOS, 64(9), 1999, pp. 1038-1048

Abstract

We have developed mathematical methods for describing ligand-receptor interactions (LRI) using Markov chains. Under some conditions, the mean value of ligand-receptor complexes obtained using Markov chains coincides with that obtained from the law of mass action. Using the calculated ratio of standard deviation to mean number of ligand-receptor complexes, we show that with small concentrations of ligand-receptor complexes LRI must be described using probability methods. Using data from the literature, we show that LRI description using the mass-action law under these conditions can cause significant errors in interpretation of experimental data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:53:52