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Titolo:
PRO-THYMOCYTE EXPANSION BY C-KIT AND THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN IS ESSENTIAL FOR REPERTOIRE FORMATION
Autore:
RODEWALD HR; OGAWA M; HALLER C; WASKOW C; DISANTO JP;
Indirizzi:
BASEL INST IMMUNOL,GRENZACHERSTR 487 CH-4005 BASEL SWITZERLAND HOP NECKER ENFANTS MALAD,INSERM,U429 F-75743 PARIS FRANCE
Titolo Testata:
Immunity
fascicolo: 3, volume: 6, anno: 1997,
pagine: 265 - 272
SICI:
1074-7613(1997)6:3<265:PEBCAT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM-CELL-FACTOR; MICE; REARRANGEMENT; PROLIFERATION; LIGAND; MOUSE; GENE; INTERLEUKIN-2; LYMPHOCYTES; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Rodewald et al., "PRO-THYMOCYTE EXPANSION BY C-KIT AND THE COMMON CYTOKINE RECEPTOR-GAMMA CHAIN IS ESSENTIAL FOR REPERTOIRE FORMATION", Immunity, 6(3), 1997, pp. 265-272

Abstract

Growth factors have been implicated in thymocyte development, but mutants lacking cytokines, or their receptors, have failed to reveal essential roles for growth/differentiation factors in the thymus. Mutations in the receptor tyrosine kinase c-kit and the common cytokine receptor gamma chain (gamma(c)) reduce cellularity, but are permissive for thymocyte development. We now report that thymocyte development is completely abrogated in mice lacking both c-kit and gamma(c) (c-kit(-)gamma(c)(-)). Thymic hypocellularity is so severe that the T cell receptorrepertoire fails to form except for monoclonal or oligoclonal beta chain DJ rearrangements. B lymphopoiesis is only mildly reduced in c-kit(-)gamma(c)(-) as compared with c-kit(+)gamma(c)(-) mice, and hematological values are identical comparing c-kit-deficient and c-kit(-)gamma(c)(-) mice. These experiments reveal essential, overlapping, and synergistic functions for two distinct signaling pathways, one utilizing c-kit and the other cytokine receptor gamma(c) complexes coupling to Janus kinases and signal transducers and activators of transcription.

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Documento generato il 27/11/20 alle ore 03:14:25