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Titolo:
Direct interaction of the beta-domain of VHL tumor suppressor protein withthe regulatory domain of atypical PKC isotypes
Autore:
Okuda, H; Hirai, S; Takaki, Y; Kamada, M; Baba, M; Sakai, N; Kishida, T; Kaneko, S; Yao, M; Ohno, S; Shuin, T;
Indirizzi:
Kochi Med Sch, Dept Urol, Kochi 7838505, Japan Kochi Med Sch Kochi Japan7838505 d Sch, Dept Urol, Kochi 7838505, Japan Yokohama City Univ, Sch Med, Dept Mol Biol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Yokohama City Univ, Sch Med, Dept Urol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 263, anno: 1999,
pagine: 491 - 497
SICI:
0006-291X(19990924)263:2<491:DIOTBO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-CELL CARCINOMA; FACTOR MESSENGER-RNA; KINASE-C ISOFORMS; SOMATIC MUTATIONS; GENE-PRODUCT; CAENORHABDITIS-ELEGANS; GROWTH; BINDING; LAMBDA; HEMANGIOBLASTOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ohno, S Kochi Med Sch, Dept Urol, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 ept Urol, Kochi 7838505, Japan
Citazione:
H. Okuda et al., "Direct interaction of the beta-domain of VHL tumor suppressor protein withthe regulatory domain of atypical PKC isotypes", BIOC BIOP R, 263(2), 1999, pp. 491-497

Abstract

VHL tumor suppressor protein contains two domains, alpha and beta. The alpha-domain is involved in the formation of a large protein complex suggestedto be involved in ubiquitin-mediated protein degradation. However, the role of the beta-domain, which may recognize the target proteins for protein degradation, remains unknown. Here we report that the beta-domain interacts directly with atypical PKC isotypes, PKC zeta and PKC lambda. Further, the regulatory domain of aPKC is sufficient for this direct protein-protein interaction. Since aPKC isotypes have been implicated in the regulation of cell growth and apoptosis, these results suggest that aPKC isotypes are potential direct target of the VHL beta-domain. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:21:59