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Titolo:
The human olivocochlear system: Organization and development
Autore:
Moore, JK; Simmons, DD; Guan, YL;
Indirizzi:
House Ear Inst, Dept Neuroanat, Los Angeles, CA 90057 USA House Ear Inst Los Angeles CA USA 90057 roanat, Los Angeles, CA 90057 USA Cent Inst Deaf, Ctr Biol Hearing & Deafness, St Louis, MO 63110 USA Cent Inst Deaf St Louis MO USA 63110 g & Deafness, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Otolaryngol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Otolaryngol, St Louis, MO 63110 USA
Titolo Testata:
AUDIOLOGY AND NEURO-OTOLOGY
fascicolo: 6, volume: 4, anno: 1999,
pagine: 311 - 325
SICI:
1420-3030(199911/12)4:6<311:THOSOA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SUPERIOR OLIVARY COMPLEX; COCHLEAR EFFERENT NEURONS; AUDITORY BRAIN-STEM; HUMAN TEMPORAL BONE; GUINEA-PIG COCHLEA; OUTER HAIR-CELLS; CHOLINE-ACETYLTRANSFERASE; VESTIBULOCOCHLEAR ANASTOMOSIS; IMMUNOCYTOCHEMICAL DETECTION;
Keywords:
efferent neurons; choline acetyltransferase; calcitonin gene-related peptide; superior olivary complex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, JK House Ear Inst, Dept Neuroanat, 2100 W 3rd St,5th Floor, Los Angeles, CA 90057 USA House Ear Inst 2100 W 3rd St,5th Floor Los Angeles CA USA 90057
Citazione:
J.K. Moore et al., "The human olivocochlear system: Organization and development", AUDIOL NEUR, 4(6), 1999, pp. 311-325

Abstract

The goals of the present study were to identify ol ivocochlear neurons in the human brainstem, to establish the time course of their early development and to compare the organization of the human olivocochlear system to thatof other mammals. To accomplish these goals, we used immunohistochemistry for choline acetyltransferase (ChAT) and calcitonin gene-related peptide (CGRP) in postmortem brainstems of human subjects ranging in age from 16 fetal weeks to 17 years. By immunostaining, we identified two classes of cells in the superior olivary complex: both classes were seen to be present from the twenty-first fetal week to the seventeenth year. Neurons which are immunostained only for ChAT are located primarily in the dorsomedial, ventral and ventrolateral sectors of the periolivary region. These neurons are predominantly bipolar or multipolar cells, and are probably homologous to medialolivocochlear neurons in other species. A second population of cells is immunoreactive for both ChAT and CGRP. This population includes a cluster of mostly small oval neurons, located on the dorsal edge of the olivary complex, and a variable number of cells found along the margin of the lateral olivary nucleus. These ChAT- and CGRP-immunoreactive cells are likely to be homologous to the lateral olivocochlear system in other mammals. With increasing age, the dorsal cluster of small cells shifts from its original cap-like position over the lateral olivary nucleus to become an extended column ofcells lying among the fibers of the olivocochlear bundle.

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Documento generato il 20/09/20 alle ore 06:44:45