Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis of new hypoxia markers EF1 and [F-18]-EF1
Autore:
Kachur, AV; Dolbier, WR; Evans, SM; Shiue, CY; Shiue, GG; Skov, KA; Baird, IR; James, BR; Li, AR; Roche, A; Koch, CJ;
Indirizzi:
Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 iat Oncol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Radiol, Philadelphia, PA 19104 USA Univ Penn, Sch Vet Med, Dept Clin Studies, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 n Studies, Philadelphia, PA 19104 USA Univ Florida, Dept Chem, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 ept Chem, Gainesville, FL 32611 USA British Columbia Canc Res Ctr, Vancouver, BC V5Z 1L3, Canada British Columbia Canc Res Ctr Vancouver BC Canada V5Z 1L3 V5Z 1L3, Canada Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada Univ British Columbia Vancouver BC Canada V6T 1Z1 ver, BC V6T 1Z1, Canada
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 6, volume: 51, anno: 1999,
pagine: 643 - 650
SICI:
0969-8043(199912)51:6<643:SONHME>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMAGING TUMOR HYPOXIA; F-18 FLUOROMISONIDAZOLE; NONINVASIVE ASSESSMENT; CELLS; CARCINOMA; INVIVO; DEPENDENCE; REDUCTION; ISCHEMIA; ADDUCTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Koch, CJ Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Philadelphia, PA 19104 USA
Citazione:
A.V. Kachur et al., "Synthesis of new hypoxia markers EF1 and [F-18]-EF1", APPL RAD IS, 51(6), 1999, pp. 643-650

Abstract

We report on the preparation of a hypoxia marker 2-(2-nitroimidazol-1[H]-yl)-N-(3-fluoropropyl)acetamide (EF1) and its F-18 analog, 2-(2-nitroimidazol-1[H]-yl)-N-(3-[F-18]fluoropropyl)acetamide ([F-18]-EF1). Two methods for the preparation of 3-fluoropropylamine, the EF1 side chain, are described. [F-18]-EF1 was prepared with a radiochemical yield of 2% by nucleophilic substitution of bromine in 2-(2-nitroimidazol-1[H]-yl)-N-(3-bromopropyl) acetamide (EBrl) by carrier-added F-18 in DMSO at 120 degrees C. Our results demonstrate the preparation of clinically relevant amounts of [F-18]-EF1 for use as a non-invasive hypoxia marker with detection using positron emission tomography (PET). (C) 1999 Elsevier Science Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 09:31:09