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Titolo:
Porous bioactive glass matrix in reconstruction of articular osteochondraldefects
Autore:
Ylanen, HO; Helminen, T; Helminen, A; Rantakokko, J; Karlsson, KH; Aro, HT;
Indirizzi:
Abo Akad Univ, Dept Chem Engn, Turku, Finland Abo Akad Univ Turku Finland o Akad Univ, Dept Chem Engn, Turku, Finland
Titolo Testata:
ANNALES CHIRURGIAE ET GYNAECOLOGIAE
fascicolo: 3, volume: 88, anno: 1999,
pagine: 237 - 245
SICI:
0355-9521(1999)88:3<237:PBGMIR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARTILAGE REPAIR; RABBIT KNEE; GRAFT; COMPOSITE; IMPLANTS; BONE;
Keywords:
articular cartilage; osteochondral defect; cartilage repair; bone repair; bioactive glass; indentation testing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Aro, HT Univ Turku, Dept Surg, FIN-20520 Turku, Finland Univ Turku TurkuFinland FIN-20520 urg, FIN-20520 Turku, Finland
Citazione:
H.O. Ylanen et al., "Porous bioactive glass matrix in reconstruction of articular osteochondraldefects", ANN CHIR GY, 88(3), 1999, pp. 237-245

Abstract

Background and Aims: This study was carried out to investigate the use of porous bioactive glass implants in promotion of articular cartilage and subchondral bone repair in large osteochondral joint defects. Material and Methods: Two conical osteochondral defects (top diameter 3.0-3.2 mm) were drilled into the patellar grooves of the distal femurs in the rabbit. The defects, extending (approximately 6-7 mm) from the surface of the articular cartilage to the subchondral marrow space, were reconstructed with size-matched porous conical implants made of sintered bioactive glass microspheres (microsphere diameter 250-300 mu m, structural implant compression strength 20-25 MPa) using press-fit technique. The implant surface wassmoothened to the level of the surrounding articular cartilage. One of thetwo defects in each femur was left empty to heal naturally and to serve asthe control. At 8 weeks, the defect healing was analyzed with use of a semiquantitative histological grading system, histomorphometry of subchondral bone repair, back-scattered electron imaging of scanning electron microscopy (BEI-SEM), and a microindentation test for characterization for the stiffness properties of the cartilage repair tissue. Results: The porous structure of the bioactive glass implants, extending from the articular defect of the patellar groove into the posterior cortex of the femur, was extensively filled by new bone. Cartilage repair varied from near-complete healing by hyaline cartilage to incomplete healing predominantly by fibrocartilage or fibrous tissue. There were, however, no statistical differences in the histological scores of repair between the glass-filled and control defects, although the sum of the averages of each category was lowest for the bioactive glass filled defects. The indentation stiffness values of all the defects were also significantly lower than that of normal cartilage on the patellar groove. Conclusions: Porous textures made by sintering bioactive glass microspheres may expand the opportunities in reconstruction of deep osteochondral defects of weight-bearing joints. The implants act mechanically as a supportingscaffold and facilitate the penetration of stromal bone marrow cells and their chondrogenic and osteogenic differentiation. Ionic properties of the bioactive glasses make the substances highly potential even as delivery systems for adjunct growth factor therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:32:02