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Titolo:
Clinical and neuroradiologic features associated with chronicity in late-life depression
Autore:
Lavretsky, H; Lesser, IM; Wohl, M; Miller, BL; Mehringer, CM;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Psychiat, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Behav Sci, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 4, volume: 7, anno: 1999,
pagine: 309 - 316
SICI:
1064-7481(199923)7:4<309:CANFAW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER HYPERINTENSITIES; CHRONIC MAJOR DEPRESSION; CHRONIC MEDICAL ILLNESS; GERIATRIC DEPRESSION; SIGNAL HYPERINTENSITIES; SEX-DIFFERENCES; LATE-ONSET; ELDERLY PATIENTS; BRAIN CHANGES; OLDER ADULTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Lavretsky, H Univ Calif Los Angeles, Inst Neuropsychiat, Room 37-425,760 Westwood Plaza, Los Angeles, CA 90024 USA Univ Calif Los Angeles Room 37-425,760 Westwood Plaza Los Angeles CA USA 90024
Citazione:
H. Lavretsky et al., "Clinical and neuroradiologic features associated with chronicity in late-life depression", AM J GER PS, 7(4), 1999, pp. 309-316

Abstract

The authors conducted a 6-year follow-up of 16 patients with late-life depression to evaluate the relationships between clinical and neuroradiologic variables and disease outcome. Patients had a comprehensive neuropsychiatric evaluation and magnetic resonance imaging (MRI) at baseline and follow-up. Eight of the IG developed a chronic course of unremitting major depression sufficient to cause significant psychosocial impairment. Six patients with a chronic course and four patients with a non-chronic course of depression had white matter hyperintensities (WMH) on MRI at baseline. Four patientswhose WMH increased in size over time developed a chronic unremitting course of depression. No patients with non-chronic depression had large areas of WMH at baseline or exhibited increased WMH size over time. Chronic depression was associated with severity of cerebrovascular risk factors, apathy, and poor quality, of life. Treatment and prevention of cerebrovascular disease may improve the outcome of late-life depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:39:56