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Titolo:
Immunostimulatory effects of human recombinant interleukin-12 on peripheral blood mononuclear cells from normal dogs
Autore:
Phillips, BS; Padilla, ML; Dickerson, EB; Lindstrom, MJ; Helfand, SC;
Indirizzi:
Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Med Sci, Madison, WI 53706 USA Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 & Med Informat, Madison, WI 53706 USA Univ Wisconsin, Ctr Comprehens Canc, Madison, WI 53706 USA Univ WisconsinMadison WI USA 53706 omprehens Canc, Madison, WI 53706 USA
Titolo Testata:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
fascicolo: 3-4, volume: 70, anno: 1999,
pagine: 189 - 201
SICI:
0165-2427(19990920)70:3-4<189:IEOHRI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELL; IFN-GAMMA PRODUCTION; STIMULATORY FACTOR NKSF; TUMOR-BEARING MICE; IN-VIVO; IL-12 RECEPTOR; ANTITUMOR; ANGIOGENESIS; ANTIBODY; CYTOKINE;
Keywords:
dog; interleukin-12; peripheral blood mononuclear cells; cytotoxicity; antibody-dependent cellular cytotoxicity; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Helfand, SC Univ Wisconsin, Sch Vet Med, Dept Med Sci, 2015 Linden Dr W, Madison, WI 53706 USA Univ Wisconsin 2015 Linden Dr W Madison WI USA 53706 53706 USA
Citazione:
B.S. Phillips et al., "Immunostimulatory effects of human recombinant interleukin-12 on peripheral blood mononuclear cells from normal dogs", VET IMMUNOL, 70(3-4), 1999, pp. 189-201

Abstract

Interleukin-12 (n-12) plays a pivotal role in regulating cellular immune responses involving autoimmunity. infectious disease. and cancer. Human recombinant (hr) IL-12 is being evaluated for therapy of human cancer. We investigated the potential of hrIL-12 to activate canine peripheral blood mononuclear cells (PBMC) using proliferation and cytotoxicity as readouts. Human rIL-12 caused increased proliferation of PBMC, and enhanced lysis of allogeneic canine tumor targets mediated by PBMC from normal dogs in vitro. In addition, antibody-dependent cellular cytotoxicity (ADCC) mediated by canine PBMC was enhanced by hrIL-12. These results indicate that hrIL-12 is recognized by canine immune cells, triggering a number of immune responses in canine PBMC, that may be important for immunotherapy of canine cancer. Information from this investigation provides impetus for evaluation of the effectsof hrIL-12 on PBMC from tumor-bearing dogs and should be helpful in the development of hrIL-12 as an immune cell activator in vivo in the dog. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:05:58