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Titolo:
Dopamine transporters and neuronal injury
Autore:
Miller, GW; Gainetdinov, RR; Levey, AI; Caron, MG;
Indirizzi:
Univ Texas, Coll Pharm, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 iv Texas, Coll Pharm, Austin, TX 78712 USA Duke Univ, Med Ctr, Durham, NC 27710 USA Duke Univ Durham NC USA 27710Duke Univ, Med Ctr, Durham, NC 27710 USA Emory Univ, Sch Med, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 mory Univ, Sch Med, Atlanta, GA 30322 USA Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 oward Hughes Med Inst, Durham, NC 27710 USA
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 10, volume: 20, anno: 1999,
pagine: 424 - 429
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR MONOAMINE TRANSPORTER; PARKINSONISM-INDUCING NEUROTOXIN; RAT-BRAIN; MPTP NEUROTOXICITY; STRIATAL DOPAMINE; KNOCKOUT MICE; CHROMAFFIN GRANULES; NUCLEUS-ACCUMBENS; COMPLEMENTARY-DNA; COCAINE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, GW Univ Texas, Coll Pharm, Austin, TX 78712 USA Univ Texas AustinTX USA 78712 oll Pharm, Austin, TX 78712 USA
Citazione:
G.W. Miller et al., "Dopamine transporters and neuronal injury", TRENDS PHAR, 20(10), 1999, pp. 424-429

Abstract

The plasma membrane dopamine transporter (DAT) and the vesicular monoaminetransporter (VMAT2) are essential for normal dopamine neurotransmission. DAT terminates the actions of dopamine by rapidly removing dopamine from thesynapse, whereas VMAT2 loads cytoplasmic dopamine into vesicles for storage and subsequent release. Recent data suggest that perturbation of the tightly regulated balance between these two transporters predisposes the neurone to damage by a variety of insults. Most notable is the selective degeneration of DAT- and VMAT2-expressing dopamine nerve terminals in the striatum thought to underlie Parkinson's disease. DAT and VMAT2 expression can predict the selective vulnerability of neuronal populations, which suggests thattherapeutic strategies aimed at altering DAT and VMAT2 function could havesignificant benefits in a variety of disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:13:03