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Titolo:
Odorant receptors: a plethora of G-protein-coupled receptors
Autore:
Dryer, L; Berghard, A;
Indirizzi:
Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA Univ Houston Houston TX USA 77204 t Biol & Biochem, Houston, TX 77204 USA Umea Univ, Dept Cell & Mol Biol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Dept Cell & Mol Biol, S-90187 Umea, Sweden
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 10, volume: 20, anno: 1999,
pagine: 413 - 417
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE PHEROMONE RECEPTORS; HUMAN OLFACTORY RECEPTORS; FUNCTIONAL EXPRESSION; MULTIGENE FAMILY; EMBRYONIC EXPRESSION; GENE FAMILY; EPITHELIUM; NEURONS; SYSTEM; RAT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Dryer, L Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA Univ Houston Houston TX USA 77204 Biochem, Houston, TX 77204 USA
Citazione:
L. Dryer e A. Berghard, "Odorant receptors: a plethora of G-protein-coupled receptors", TRENDS PHAR, 20(10), 1999, pp. 413-417

Abstract

Odorant receptors (ORs) comprise the largest family of G-protein-coupled receptors (GPCRs). They are located in the nasal epithelium, at the ciliatedsurface of olfactory sensory neurones, where the initial steps of the olfactory transduction cascade occur. ORs are encoded by a large and diverse multi-gene family, which has been characterized in cyclostomes, teleosts, amphibia, birds and mammals, as well as in Drosophila and Caenorhabditis elegans. Here, the range of diversity in OR and chemoreceptor structure is examined, noting that their functions are fundamentally similar to those of manyneurotransmitter or neurohormone receptors. It is argued that ORs have emerged directly from other GPCRs Independently in many species. According to this view, there is no structural prerequisite for OR identity and any GPCRhas the potential to be or become an OR at a given point in evolution.

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Documento generato il 21/09/20 alle ore 16:47:17