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Titolo:
Co-administration of toluene and xylene antagonized the testicular toxicity but not the hematopoietic toxicity caused by ethylene glycol monoethyl ether in Sprague-Dawley rats
Autore:
Yu, IJ; Lee, JY; Chung, YH; Kim, KJ; Han, JH; Cha, GY; Chung, WG; Cha, YM; Park, JD; Lee, YM; Moon, YH;
Indirizzi:
Korea Ind Safety Corp, Ind Safety & Hlth Res Inst, Ind Chem Res Ctr, Yusung Gu, Taejon 305380, South Korea Korea Ind Safety Corp Taejon South Korea305380 ejon 305380, South Korea Inha Univ, Coll Med, Dept Pharmacol, Inchon, South Korea Inha Univ Inchon South Korea l Med, Dept Pharmacol, Inchon, South Korea Chung Ang Univ, Coll Med, Dept Prevent Med, Seoul 156756, South Korea Chung Ang Univ Seoul South Korea 156756 t Med, Seoul 156756, South Korea
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-2, volume: 109, anno: 1999,
pagine: 11 - 20
SICI:
0378-4274(19990920)109:1-2<11:COTAXA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC-SOLVENTS; EXPOSURE;
Keywords:
ethylene glycol monoethyl ether; seminiferous tubule degeneration; hematology; toluene; xylene; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, IJ Korea Ind Safety Corp, Ind Safety & Hlth Res Inst, Ind Chem Res Ctr, Yusung Gu, 104-8 Moonji Dong, Taejon 305380, South Korea Korea Ind SafetyCorp 104-8 Moonji Dong Taejon South Korea 305380
Citazione:
I.J. Yu et al., "Co-administration of toluene and xylene antagonized the testicular toxicity but not the hematopoietic toxicity caused by ethylene glycol monoethyl ether in Sprague-Dawley rats", TOX LETT, 109(1-2), 1999, pp. 11-20

Abstract

Occupational painters are exposed to ethylene glycol monoethyl ether (EGEE), a widely used emulsifying solvent known to cause testicular degenerationand bone marrow depression, together with toluene (TOL) and xylene (XYL) as a mixture. In the previous study (Chung et al., Tox. Lett. 104.143, 1999), testicular atrophy caused by EGEE (200 mg/kg) was shown to be antagonizedby co-administration of TOL (250 mg/kg) and XYL (500 mg/kg). This study was conducted to provide histological support for the previously observed antagonistic protective effect of TOL + XYL on EGEE inducible testicular toxicity and to determine whether a similar antagonistic effect can be demonstrated against the EGEE derived hematopoietic toxicity. Compared to the extentof seminiferous tubule degeneration caused by EGEE (150 mg/kg, six times per week for 4 weeks), testes of rats given co-administration of TOL (150 mg/kg) + XYL (500 mg/kg) showed dramatically reduced tubular degeneration. Hyperplasia of Leydig cells in the interstitium was observed in both EGEE andEGEE + TOL + XYL treated rats. Although a minimal dose of EGEE causing testicular atrophy was used, WBC and platelet counts were decreased significantly. In the TOL + XYL-treated control group, the WBC and platelet counts were not decreased. However, the bone marrow depression caused by EGEE was not reversed by the combined administration of TOL + XYL. In all experimentalgroups (EGEE alone, TOL + XYL, EGEE + TOL + XYL), plasma levels of creatinine and alkaline phosphatase were significantly decreased. In addition to the marked testicular atrophy, EGEE also decreased the weights of adrenal glands and epididymis. Tn conclusion, while the testicular degeneration caused by EGEE was antagonized by TOL + XYL, the EGEE derived hematopoietic suppression was not reversed. (C) 1999 Elsevier Science Ireland Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:15:39